A GPT-2 model fine-tuned with disease MeSH + protein sequence inputs and GRPO rewards produces more unique, valid, drug-like, high-PLAPT-affinity ligands than DrugGPT or DrugGen on five diabetic-nephropathy targets.
Complementary Approaches to Existing Tar- get Based Drug Discovery for Identifying Novel Drug Targets.Biomedicines
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DrugGen 2: A disease-aware language model for enhancing drug discovery
A GPT-2 model fine-tuned with disease MeSH + protein sequence inputs and GRPO rewards produces more unique, valid, drug-like, high-PLAPT-affinity ligands than DrugGPT or DrugGen on five diabetic-nephropathy targets.