A new Bayesian phase I/II basket trial design (DF-EXNEX) with extended EXNEX mixture priors for robust borrowing across subtrials to select subtrial-specific optimal biological doses, shown in simulations to outperform no-borrowing in most of 70 scenarios.
and Mozgunov, Pavel , title =
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A Bayesian Phase I/II basket design with robust information borrowing to identify subtrial-specific optimal biological doses
A new Bayesian phase I/II basket trial design (DF-EXNEX) with extended EXNEX mixture priors for robust borrowing across subtrials to select subtrial-specific optimal biological doses, shown in simulations to outperform no-borrowing in most of 70 scenarios.