Simulation study shows longitudinal models flexibly adjusting for irregular assessment timing yield unbiased treatment effect estimates in pragmatic trials with uncontrolled EHR outcomes, unlike naive single-score approaches that introduce substantial bias.
Longitudinal data subject to irregular observation: A review of methods with a focus on visit processes, assumptions, and study design
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Statistical Design of Pragmatic Trials Using Electronic Health Record Data when Outcome Assessments are Uncontrolled and Irregular
Simulation study shows longitudinal models flexibly adjusting for irregular assessment timing yield unbiased treatment effect estimates in pragmatic trials with uncontrolled EHR outcomes, unlike naive single-score approaches that introduce substantial bias.