In MD simulations, urea displaces water from the BSA surface until urea-urea clustering takes over, leaving BSA's secondary structure nearly unchanged while Domain III becomes more exposed.
Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding
1 Pith paper cite this work. Polarity classification is still indexing.
1
Pith paper citing it
citation-role summary
background 1
citation-polarity summary
fields
physics.bio-ph 1years
2026 1verdicts
REJECT 1roles
background 1polarities
background 1representative citing papers
citing papers explorer
-
Urea-Mediated Solvent Reorganization of Bovine Serum Albumin in an Acid-Induced Expanded Conformation at pH 3.7
In MD simulations, urea displaces water from the BSA surface until urea-urea clustering takes over, leaving BSA's secondary structure nearly unchanged while Domain III becomes more exposed.