A drop-the-loser multi-stage design with superiority stopping boundaries reduces expected sample size while controlling type I error and power, and lowers maximum sample size versus traditional MAMS trials.
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A Multi-Stage Drop-the-Loser Design with Superiority Boundaries
A drop-the-loser multi-stage design with superiority stopping boundaries reduces expected sample size while controlling type I error and power, and lowers maximum sample size versus traditional MAMS trials.