By fitting a TAD-based DSB classification model to cell survival curves, the authors find that per-event lethality is highest for DSBs in frequently interacting TADs, intermediate for clustered DSBs in one TAD, and lowest for isolated DSBs.
How does radiation kill cells? Current Opinion in Chemical Biology
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Correlation Between DNA Double-Strand Break Distribution in 3D Genome and Radiation-Induced Cell Death
By fitting a TAD-based DSB classification model to cell survival curves, the authors find that per-event lethality is highest for DSBs in frequently interacting TADs, intermediate for clustered DSBs in one TAD, and lowest for isolated DSBs.