SAFE is a new two-layer framework that assesses drug safety in clinical trials by analyzing synergy areas with compelling evidence and controlling FDR across areas, as shown in simulations and real-data case studies.
The utility of troponin measurement to detect myocardial infarction: review of the current findings.Vascular Health and Risk Management2010: 691–699
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Synergy Area with FDR-controlled Evaluation (SAFE) to robustly assess safety profile in clinical trials
SAFE is a new two-layer framework that assesses drug safety in clinical trials by analyzing synergy areas with compelling evidence and controlling FDR across areas, as shown in simulations and real-data case studies.