Three new BOIN variants (BOIN-CS, BOIN-CE, BOIN-CB) adapt the Bayesian optimal interval framework to selected dose combinations in dual-agent phase I trials and show acceptable performance in simulations.
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BOIN Designs for Dose Escalation With Selected Dose Combinations in Oncology Phase I Trials
Three new BOIN variants (BOIN-CS, BOIN-CE, BOIN-CB) adapt the Bayesian optimal interval framework to selected dose combinations in dual-agent phase I trials and show acceptable performance in simulations.