Urea induces concentration-dependent dehydration/rehydration of BSA's hydration shell at pH 3.7 via competitive solvation and self-association, preserving secondary structure but increasing flexibility especially in Domain III.
Impact of urea on water structure: a clue to its properties as a denaturant? Biophysical chemistry 2003, 105, 649--666
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Molecular Mechanisms of Urea Interactions with Bovine Serum Albumin in an Acid-Expanded Conformation (pH 3.7)
Urea induces concentration-dependent dehydration/rehydration of BSA's hydration shell at pH 3.7 via competitive solvation and self-association, preserving secondary structure but increasing flexibility especially in Domain III.