In a computer model of human heart tissue, stretch-activated currents cause an instability where action potential duration grows beat by beat, leading to wave break and spiral wave meandering.
Gerisch, Wilhelm Roux’ Archiv f¨ ur Entwick- lungsmechanik der Organismen 156, 127 (1965)
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Cardiac Mechano-Electrical Dynamical Instability
In a computer model of human heart tissue, stretch-activated currents cause an instability where action potential duration grows beat by beat, leading to wave break and spiral wave meandering.