Cross-modal distillation transfers spatial transcriptomics-derived tissue niche structures to histology-only models, yielding higher agreement with molecular niches than unsupervised image-feature baselines across tissues and diseases.
Deep generative modeling for single- cell transcriptomics.Nature Methods, 15(12):1053–1058,
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Cross-Modal Knowledge Distillation from Spatial Transcriptomics to Histology
Cross-modal distillation transfers spatial transcriptomics-derived tissue niche structures to histology-only models, yielding higher agreement with molecular niches than unsupervised image-feature baselines across tissues and diseases.