FILM microscopy with AI-assisted denoising maps metabolic heterogeneity and dysfunction in lysosomes of living cells and organisms, revealing lipolysis/proteolysis variations, early aging effects, and disease-associated changes.
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Chem-SIM achieves super-resolved chemical imaging of cells by demodulating photothermal modulation of structured-illumination fluorescence to extract vibrational spectra.
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FILM: Mapping organellar metabolism by mid-infrared photothermal modulated fluorescence
FILM microscopy with AI-assisted denoising maps metabolic heterogeneity and dysfunction in lysosomes of living cells and organisms, revealing lipolysis/proteolysis variations, early aging effects, and disease-associated changes.
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Chem-SIM: Super-resolution Chemical Imaging via Photothermal Modulation of Structured-Illumination Fluorescence
Chem-SIM achieves super-resolved chemical imaging of cells by demodulating photothermal modulation of structured-illumination fluorescence to extract vibrational spectra.