A new multiscale framework combines single-cell kinetic metabolic-glycosylation models with stochastic population dynamics and an oxygen uptake biomarker to predict cell density, metabolites, productivity, and glycan profiles in mammalian cell cultures.
Neutralization of ph in the golgi apparatus causes redistribution of glycosyltransferases and changes in the o-glycosylation of mucins.Glycobiology, 11(8):633–644, 2001
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GlycoMAC: A Multiscale Metabolic-Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures
A new multiscale framework combines single-cell kinetic metabolic-glycosylation models with stochastic population dynamics and an oxygen uptake biomarker to predict cell density, metabolites, productivity, and glycan profiles in mammalian cell cultures.