A new benchmarking framework shows virtual cell models overestimate performance on standard tests, drop sharply on unseen contexts and perturbations, and produce inconsistent rankings across metrics.
Predicting cellular responses to novel drug perturbations at a single-cell resolution.Advances in Neural Information Processing Systems, 35:26711–26722
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Benchmarking virtual cell models for in-the-wild perturbation response
A new benchmarking framework shows virtual cell models overestimate performance on standard tests, drop sharply on unseen contexts and perturbations, and produce inconsistent rankings across metrics.