A two-step approach derives biomarker variability measures from mixed-effects residuals and includes them in standard joint models to estimate their association with time-to-event outcomes.
Peripheral Blood Biomarkers Associated with Clinical Outcome in Non–Small Cell Lung Cancer Patients Treated with Nivolumab.Journal of Thoracic Oncology, 13(1):97–105
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Joint modelling of time-dependent biomarker variability and time-to-event outcomes, a two-step approach
A two-step approach derives biomarker variability measures from mixed-effects residuals and includes them in standard joint models to estimate their association with time-to-event outcomes.