A dual-decoder variational autoencoder reconstructs single-cell Raman spectra from brightfield images with ~98% cosine similarity and discriminates bacterial transgenic states at 88% accuracy.
To correct for cosmic ray spikes, each raw spectrum was passed through a 1D median filter, and an intensity vector was computed using a kernel size of 5 points
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2026 1verdicts
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Pic2Spec: Generative Modeling Reconstructs Single Cell Raman Fingerprints from Brightfield Images
A dual-decoder variational autoencoder reconstructs single-cell Raman spectra from brightfield images with ~98% cosine similarity and discriminates bacterial transgenic states at 88% accuracy.