For cooperative single-enzyme kinetics, the first-passage time fluctuation theorem holds exactly when the hidden conformational current vanishes, and the leading correction is a thermodynamic bound on the branching ratio.
In our model, the addition of the hidden loop and the effect of the kinetic reversibility significantly complicate the calculations forP ± (t)
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First-Passage Time Fluctuation Theorem and Thermodynamic Bound in Cooperative Biomolecular Networks
For cooperative single-enzyme kinetics, the first-passage time fluctuation theorem holds exactly when the hidden conformational current vanishes, and the leading correction is a thermodynamic bound on the branching ratio.