With a developmentally matched stimulation-naive control, repeated daily HD-MEA stimulation depresses and spatially contracts organoid evoked responses (~10% vs ~93% array engagement at day 7), while the response itself is near-synchronous, not a propagating wave.
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Stimulus-Evoked Network Dynamics in Human Cortical Organoids: From a Graph-Computational Framework to Repeated-Stimulation Depression
With a developmentally matched stimulation-naive control, repeated daily HD-MEA stimulation depresses and spatially contracts organoid evoked responses (~10% vs ~93% array engagement at day 7), while the response itself is near-synchronous, not a propagating wave.