ContextFlow regularizes flow matching with a transition plausibility matrix built from local tissue organization and ligand-receptor patterns to produce statistically and biologically coherent trajectories from longitudinal spatial omics data.
Equation 16 can be solved in a mini-batch fashion using standard solvers such as POT (Flamary et al., 2021); however, the computational complexity is cubic in batch size
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ContextFlow: Context-Aware Flow Matching For Trajectory Inference From Spatial Omics Data
ContextFlow regularizes flow matching with a transition plausibility matrix built from local tissue organization and ligand-receptor patterns to produce statistically and biologically coherent trajectories from longitudinal spatial omics data.