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arxiv: 1004.1866 · v1 · pith:YDJQE4W7new · submitted 2010-04-12 · 🧮 math.AP · math.NA

Existence and stability of steady states of a reaction convection diffusion equation modeling microtubule formation

classification 🧮 math.AP math.NA
keywords microtubulestabilitydynamicsexistencefunctionmodelstatessteady
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We generalize the Dogterom-Leibler model for microtubule dynamics [DL] to the case where the rates of elongation as well as the lifetimes of the elongating and shortening phases are a function of GTP-tubulin concentration. We study also the effect of nucleation rate in the form of a damping term which leads to new steady-states. For this model, we study existence and stability of steady states satisfying the boundary conditions at x = 0. Our stability analysis introduces numerical and analytical Evans function computations as a new mathematical tool in the study of microtubule dynamics.

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