Dynamics of center-periphery patterns in knowledge networks - the case of China's biotech science and technology system

Science and technology systems - and their epistemic communities - are usually hierarchical and composed of a number of strong, large, leading organizations, along with a number of smaller and less influential ones. Moreover, these hierarchical patterns have a spatial structure: the leading organizations are concentrated in a few places, creating a science and technology center, whereas the majority of locations are peripheral. In the example of biotech research in China, we found dynamic changes in center-periphery patterns. These results are based on a network analysis of evolving co-authorship networks from 2001 to 2009 that were built combining national and international databases. Therefore, our results are not only relevant for evaluating the spatial structure and dynamics in the Chinese biotech system and its integration into the global knowledge network, but also revive a discussion on persistence and processes of change in the systems theory for sciencebased industries.