Effectivity of Iitaka fibrations and pluricanonical systems of polarized pairs

For every smooth complex projective variety $W$ of dimension $d$ and nonnegative Kodaira dimension, we show the existence of a universal constant $m$ depending only on $d$ and two natural invariants of the very general fibres of an Iitaka fibration of $W$ such that the pluricanonical system $|mK_W|$ defines an Iitaka fibration. This is a consequence of a more general result on polarized adjoint divisors. In order to prove these results we develop a generalized theory of pairs, singularities, log canonical thresholds, adjunction, etc.