Spectral theory of von Neumann algebra valued differential operators over non-compact manifolds

We provide criteria for self-adjointness and {\tau}-Fredhomness of first and second order differential operators acting on sections of infinite dimensional bundles, whose fibers are modules of finite type over a von Neumann algebra A endowed with a trace {\tau}. We extend the Callias-type index to operators acting on sections of such bundles and show that this index is stable under compact perturbations.