Quotients of spectra of almost factorial domains and Mori dream spaces

We prove that a GIT chamber quotient of an affine variety $X=Spec(A)$ by a reductive group $G$, where $A$ is an almost factorial domain, is a Mori dream space if it is projective, regardless of the codimension of the unstable locus. This includes an explicit description of the Picard number, the pseudoeffective cone, and the Mori chambers in terms of GIT. We apply the results to quiver moduli, to show that they are Mori dream spaces if the quiver contains no oriented cycles, and if stability and semistability coincide. We give a formula for the Picard number in quiver terms. As a second application we prove that geometric quotients of Mori dream spaces are Mori dream spaces as well, which again includes a description of the Picard number and the Mori chambers. Some examples are given to illustrate the results.