Ultrasensitive biosensor based on Nd:YAG waveguide laser: Tumor cell and Dextrose solution

This work demonstrates the Nd:YAG waveguide laser as an efficient platform for the bio-sensing. The waveguide was fabricated in the Nd:YAG crystal by the cooperation of the ultrafast laser writing and ion irradiation. As the laser oscillation in the Nd:YAG waveguide is ultra-sensitivity to the external environment of the waveguide. Even a weak disturbance would induce a large variation of the output power of the laser. According to this feature, the Nd:YAG waveguide coated with Graphene and WSe2 layers is used as substrate for the microfluidic channel. When the microflow crosses the Nd:YAG waveguide, the laser oscillation in the waveguide is disturbed, and induces the fluctuation of the output laser. Through the analysis of the fluctuation, the concentration of the dextrose solution and the size of the tumor cell are distinguished