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arxiv: 2108.07660 · v1 · pith:SLMTOXEYnew · submitted 2021-08-17 · 🧬 q-bio.BM

New views of old proteins: clarifying the enigmatic proteome

Participants in a NIH Workshop on Functional , Integrative Proteomics: Kristin E. Burnum Johnson (1) , Thomas P. Conrads (2) , Richard R. Drake (3) , Amy E. Herr (4) , Ravi Iyengar (5) , Ryan T. Kelly (6) , Emma Lundberg (7)
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Michael J. MacCoss (8) Alexandra Naba (9) Garry P. Nolan (10) Pavel A. Pevzner (11) Karin D. Rodland (12) Salvatore Sechi (13) Nikolai Slavov (14) Jeffrey M. Spraggins (15) Jennifer E. Van Eyk (16) Marc Vidal (17) Christine Vogel (18) David R. Walt (19) Neil L. Kelleher (20) ((1) Pacific Northwest National Laboratory (2) Inova Health System (3) Medical University of South Carolina (4) University of California Berkeley (5) Icahn School of Medicine at Mount Sinai (6) Brigham Young University (7) KTH Royal Institute of Technology (8) University of Washington (9) University of Illinois at Chicago (10) Stanford University (11) University of California at San Diego (12) Pacific Northwest National Laboratory (13) National Institutes of Health (14) Northeastern University (15) Vanderbilt University (16) Cedars Sinai Medical Center (17) Harvard University (18) New York University (19) Harvard Medical School (20) Northwestern University)
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classification 🧬 q-bio.BM
keywords proteinshumanproteomequantifyacrossapproachesbetterbiology
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All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide provocative projections for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we offer potential futures for a next generation of disruptive approaches to define, quantify and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.

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