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arxiv: 2408.07721 · v2 · pith:D36F66HDnew · submitted 2024-08-14 · 🧬 q-bio.OT

DOME Registry: Implementing community-wide recommendations for reporting supervised machine learning in biology

Omar Abdelghani Attafi (1) , Damiano Clementel (1) , Konstantinos Kyritsis (2) , Emidio Capriotti (3) , Gavin Farrell (4) , Styliani-Christina Fragkouli (2 , 5) , Leyla Jael Castro (6)
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Andr\'as Hatos (7 8 9 10) Tom Lenaerts (11 12 13) Stanislav Mazurenko (14 15) Soroush Mozaffari (1) Franco Pradelli (1) Patrick Ruch (16 17) Castrense Savojardo (3) Paola Turina (3) Federico Zambelli (18 19) Damiano Piovesan (1) Alexander Miguel Monzon (20) Fotis Psomopoulos (2) Silvio C.E. Tosatto (1 21) ((1) Department of Biomedical Sciences University of Padova Italy (2) Institute of Applied Biosciences Centre for Research Technology Hellas Thessaloniki Greece (3) Department of Pharmacy Biotechnology University of Bologna Bologna Italy (4) ELIXIR Hub Hinxton Cambridge UK (5) Department of Biology National Kapodistrian University of Athens Athens Greece (6) ZB Med Information Centre for Life Sciences Cologne Germany (7) Department of Oncology Geneva University Hospitals Geneva Switzerland (8) Department of Computational Biology University of Lausanne Lausanne Switzerland (9) Swiss Institute of Bioinformatics Lausanne Switzerland (10) Swiss Cancer Center L\'eman Lausanne Switzerland (11) Interuniversity Institute of Bioinformatics in Brussels Universit\'e Libre de Bruxelles Vrije Universiteit Brussel Brussels Belgium (12) Machine Learning Group Universit\'e Libre de Bruxelles Street Belgium (13) Artificial Intelligence Laboratory Vrije Universiteit Brussels Brussels Belgium (14) Loschmidt Laboratories Department of Experimental Biology RECETOX Faculty of Science (15) Masaryk University Brno Czech Republic International Clinical Research Centre St Anne's Hospital Brno Czech Republic (16) HES-SO - HEG Geneva Geneva Switzerland (17) SIB Swiss Institute of Bioinformatics Geneva Switzerland (18) Dept of Biosciences University of Milan Italy (19) Institute of Biomembranes Bioenergetics Molecular Biotechnologies Bari Italy (20) Department of Information Engineering University of Padova Italy (21) Institute of Biomembranes Bioenergetics Molecular Biotechnologies National Research Council Bari Italy)
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keywords domeregistryrecommendationsbiologycomprehensivedataensureevaluation
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Supervised machine learning (ML) is used extensively in biology and deserves closer scrutiny. The DOME recommendations aim to enhance the validation and reproducibility of ML research by establishing standards for key aspects such as data handling and processing, optimization, evaluation, and model interpretability. The recommendations help to ensure that key details are reported transparently by providing a structured set of questions. Here, we introduce the DOME Registry (URL: registry.dome-ml.org), a database that allows scientists to manage and access comprehensive DOME-related information on published ML studies. The registry uses external resources like ORCID, APICURON and the Data Stewardship Wizard to streamline the annotation process and ensure comprehensive documentation. By assigning unique identifiers and DOME scores to publications, the registry fosters a standardized evaluation of ML methods. Future plans include continuing to grow the registry through community curation, improving the DOME score definition and encouraging publishers to adopt DOME standards, promoting transparency and reproducibility of ML in the life sciences.

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