A Mapping Sheath with Thermally Drawn Multi-Electrode Basket for Cardiac Electrophysiological Recording and Ablation Catheter Delivery

Alex Ranne; Anil Demircali; Burak Temelkuran; Elaine Lim; Emmanuel Drakakis; Huiyi Wu; Jamie Kay; Jinshi Zhao; Libaihe Tian; Mohamed Abdelaziz

arxiv: 2606.29634 · v1 · pith:3DZBO7Z3new · submitted 2026-06-28 · ⚛️ physics.med-ph

A Mapping Sheath with Thermally Drawn Multi-Electrode Basket for Cardiac Electrophysiological Recording and Ablation Catheter Delivery

Qindong Zheng , Anil Demircali , Jinshi Zhao , Xiaotong Guo , Libaihe Tian , Oliver Jones , Jamie Kay , Shengzhe Li

show 9 more authors

Alex Ranne Elaine Lim Huiyi Wu Simos Koutsoftidis Mohamed Abdelaziz Emmanuel Drakakis Prapa Kanagaratnam Nick Linton Burak Temelkuran

This is my paper

Pith reviewed 2026-06-30 01:33 UTC · model grok-4.3

classification ⚛️ physics.med-ph

keywords cardiac electrophysiologymapping sheaththermal drawingmulti-electrode basketablation catheter deliveryelectrogram recordingvoltage mappingporcine model

0 comments

The pith

A thermally drawn multi-electrode basket sheath integrates cardiac electrogram recording with ablation catheter delivery in one platform.

A machine-rendered reading of the paper's core claim, the machinery that carries it, and where it could break.

The paper introduces a hollow-core sheath functionalized with an adjustable basket of ultrathin electrodes at its distal end, fabricated through thermal drawing to enable both mapping and therapy delivery without separate devices. Bench-top, phantom, ex vivo, and in vivo porcine tests establish that the device supports vascular navigation, fluoroscopic visualization, tissue contact, signal acquisition, and construction of voltage and activation maps. A sympathetic reader would care because conventional electrophysiology procedures typically require repeated catheter exchanges and multiple access points, adding time and complexity to arrhythmia treatment.

Core claim

The mapping sheath exhibits mechanical and electrophysiological properties suitable for intracardiac navigation and electrogram recording, with in vivo porcine studies confirming translational feasibility through vascular introduction, fluoroscopic visualization, intracardiac deployment, tissue contact, electrogram acquisition, and reconstruction of voltage and activation maps.

What carries the argument

Adjustable basket of ultrathin electrode splines arranged circumferentially at the distal end of the hollow-core sheath, produced by thermal drawing.

If this is right

Single compact platform reduces repeated catheter exchanges and multiple access routes during electrophysiology procedures.
Enables simultaneous electrogram recording and ablation catheter delivery within the same sheath.
Supports reconstruction of voltage and activation maps from acquired signals in the left atrium.
Allows scalable manufacturing of complex electrode geometries via thermal drawing.

Where Pith is reading between the lines

These are editorial extensions of the paper, not claims the author makes directly.

The approach could shorten overall procedure duration by eliminating device swaps.
Similar integrated sheaths might apply to other cardiac chambers or non-cardiac minimally invasive interventions.
Rapid prototyping with thermal drawing could accelerate iteration on electrode count or spline spacing for specific arrhythmia targets.

Load-bearing premise

The mechanical and electrical performance observed in porcine models will translate directly to human cardiac anatomy and electrophysiology without major redesign or additional safety issues.

What would settle it

Failure to obtain accurate electrograms or safe deployment when the device is tested in human subjects would disprove the claim of translational feasibility.

read the original abstract

Cardiac arrhythmias, particularly atrial fibrillation, represent a major cardiovascular health burden and underscore the need for efficient and integrated strategies for electrical mapping and targeted therapy. Cardiac electrophysiology procedures depend on accurate identification of arrhythmogenic substrates followed by timely catheter ablation, but conventional diagnostic and therapeutic devices remain separate, often requiring repeated catheter exchanges and multiple access routes. Here, we report an adaptable strategy for functionalizing hollow-core sheaths with EP mapping capabilities, integrating multielectrode recording and ablation catheter delivery within a single compact platform. The device leverages thermal drawing to enable complex geometric fabrication, miniaturization, rapid prototyping, and scalable manufacturing of ultrathin electrode splines arranged circumferentially at the distal end to form an adjustable basket. The mapping sheath exhibited mechanical and electrophysiological properties suitable for intracardiac navigation and electrogram recording in bench-top evaluations, an in vitro left atrial phantom study, and ex vivo Langendorff-perfused porcine heart testing. In vivo porcine studies further demonstrated translational feasibility through vascular introduction, fluoroscopic visualization, intracardiac deployment, tissue contact, electrogram acquisition, and reconstruction of voltage and activation maps. These results support the development of intracardiac platforms with an adapted manufacturing approach, potentially guiding advances in agile cardiac mapping and ablation.

Editorial analysis

A structured set of objections, weighed in public.

Desk editor's note, referee report, simulated authors' rebuttal, and a circularity audit. Tearing a paper down is the easy half of reading it; the pith above is the substance, this is the friction.

Desk Editor's Note private letter to a colleague

Thermal drawing lets them build an integrated mapping sheath with electrode basket for dual recording and ablation delivery, shown to work across bench-to-in-vivo pig tests, but the translational claim rests on unbridged porcine-to-human assumptions.

read the letter

The main thing to know is that this is a device fabrication paper. They use thermal drawing to create ultrathin electrode splines arranged in a basket at the end of a hollow sheath, so the same platform can record electrograms and deliver an ablation catheter without swapping tools.

The fabrication approach is the actual novelty here. Thermal drawing supports the complex circumferential geometry and miniaturization in a way that seems practical for scaling. The testing sequence is also done right: bench-top checks, left atrial phantom, ex vivo Langendorff pig hearts, then in vivo porcine vascular access and map reconstruction. That progression shows the basic mechanical and electrical functions hold up in the models they used.

The soft spot is exactly the one flagged in the stress test. All the in vivo work is in pigs, and the abstract jumps straight to translational feasibility without any quantitative comparison of atrial size, wall thickness, or conduction differences that could affect basket contact or signal quality. If the full paper has no bridging data or discussion of those species gaps, the feasibility claim stays preliminary.

This is for people building or evaluating cardiac EP devices. Someone working on catheter integration or new manufacturing routes would get concrete ideas from the methods. It deserves peer review because the multi-stage physical testing is there and the clinical problem is real, even if the human translation section needs more work.

Referee Report

2 major / 0 minor

Summary. The manuscript presents the development of a mapping sheath functionalized with a thermally drawn multi-electrode basket for cardiac electrophysiological recording and ablation catheter delivery. The central claim is that the device demonstrates suitable mechanical and electrophysiological properties for intracardiac navigation, electrogram recording, and map reconstruction in bench-top, in vitro phantom, ex vivo Langendorff porcine heart, and in vivo porcine studies, thereby supporting translational feasibility.

Significance. If validated with quantitative data, this integrated platform could reduce the need for multiple catheter exchanges in EP procedures for atrial fibrillation, offering a more efficient approach. The thermal drawing method for creating the multi-electrode basket represents a promising manufacturing technique for complex, miniaturized devices. The work addresses a practical clinical need but its significance is tempered by the current lack of detailed performance metrics and human-relevant validation.

major comments (2)

Abstract: The claim that the mapping sheath 'exhibited mechanical and electrophysiological properties suitable for intracardiac navigation and electrogram recording' lacks any supporting quantitative data, error bars, statistical analysis, or detailed methods, which is load-bearing for establishing the feasibility of the device.
Abstract: The in vivo porcine studies are used to demonstrate 'translational feasibility', but there is no discussion or data addressing the differences in cardiac anatomy and electrophysiology between porcine and human models (e.g., left atrial size, wall thickness, conduction properties), which is essential for the translational claim to hold.

Simulated Author's Rebuttal

2 responses · 0 unresolved

We thank the referee for their thoughtful review and constructive comments. We address each major comment below and outline revisions to strengthen the manuscript.

read point-by-point responses

Referee: Abstract: The claim that the mapping sheath 'exhibited mechanical and electrophysiological properties suitable for intracardiac navigation and electrogram recording' lacks any supporting quantitative data, error bars, statistical analysis, or detailed methods, which is load-bearing for establishing the feasibility of the device.

Authors: We agree that the abstract would be strengthened by including quantitative support. The full manuscript reports specific mechanical metrics (e.g., deflection angles, insertion forces) and electrophysiological metrics (e.g., electrogram amplitudes, SNR values, mapping resolution) with error bars and statistical comparisons in the Results and Methods sections. We will revise the abstract to incorporate key quantitative findings and reference the supporting data. revision: yes
Referee: Abstract: The in vivo porcine studies are used to demonstrate 'translational feasibility', but there is no discussion or data addressing the differences in cardiac anatomy and electrophysiology between porcine and human models (e.g., left atrial size, wall thickness, conduction properties), which is essential for the translational claim to hold.

Authors: We acknowledge this is a valid point for any translational claim. Porcine models are standard for cardiac EP device testing due to comparable heart size and arrhythmia inducibility, but differences exist (e.g., smaller left atrial dimensions and faster conduction velocities in pigs). We will add a dedicated paragraph in the Discussion section summarizing these known anatomical and electrophysiological differences, their potential impact on device performance, and the need for future human validation studies. revision: yes

Circularity Check

0 steps flagged

No circularity: pure experimental device development with no derivations or self-referential modeling

full rationale

This is an experimental device paper reporting fabrication via thermal drawing and performance testing in bench, phantom, ex vivo porcine, and in vivo porcine models. No equations, fitted parameters, predictions, or mathematical derivations appear in the abstract or described content. All claims rest on direct physical results (navigation, contact, electrogram recording, map reconstruction) rather than any self-definition, fitted-input-as-prediction, or self-citation chain. The reader's assessment of score 1.0 aligns with a minimal non-circular finding; the translation assumption to humans is a validity concern, not a circularity reduction.

Axiom & Free-Parameter Ledger

0 free parameters · 1 axioms · 1 invented entities

The central claim rests on the successful fabrication via thermal drawing and the assumption that animal model results indicate translational feasibility. No free parameters are present as this is not a modeling paper. The main domain assumption is that the manufacturing process yields electrodes with adequate mechanical and electrical properties for intracardiac use.

axioms (1)

domain assumption Thermal drawing enables complex geometric fabrication of ultrathin electrode splines arranged circumferentially to form an adjustable basket with suitable properties for intracardiac navigation and recording.
Invoked in the description of the device fabrication and properties in the abstract.

invented entities (1)

Thermally drawn multi-electrode basket sheath no independent evidence
purpose: To provide an integrated platform for EP mapping and ablation catheter delivery within a single compact device.
The specific device design is the central contribution introduced in the paper; independent evidence is limited to the described tests.

pith-pipeline@v0.9.1-grok · 5834 in / 1455 out tokens · 56135 ms · 2026-06-30T01:33:06.248647+00:00 · methodology

discussion (0)

Reference graph

Works this paper leans on

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Iwasaki, K

Y.-K. Iwasaki, K. Nishida, T. Kato, S. Nattel, Atrial Fibrillation Pathophysiology. Circulation 124, 2264–2274 (2011)

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2020

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Kashyap, A

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2020

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flounder

X. Shen, E. Jia, Y. Huang, D. Ge, Z. Sun, Z. Yang, P. Zhang, Y. Chen, X. Feng, Bioinspired balloon catheter integrated with stretchable “flounder” electrodes under high voltage for uniform pulsed field ablation. Science Advances 10, (2024)

2024

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Parameswaran, A

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