Stability of holonomicity over quasi-projective varieties

Let $\V$ be a mixed characteristic complete discrete valuation ring with perfect residue field $k$. We solve Berthelot's conjectures on the stability of the holonomicity over smooth projective formal $\V$-schemes. Then we build a category of complexes of arithmetic $\D$-modules over quasi-projective $k$-varieties with bounded, $F$-holonomic cohomology. We get its stability under Grothendieck's six operations.