The evolution of massive and very massive stars in clusters

The present paper reviews massive star (initial mass smaller than 120 M0) and very massive star (initial mass larger than 120 M0) evolution. I will focus on evolutionary facts and questions that may critically affect predictions of population and spectral synthesis of starburst regions. We discuss the ever-lasting factor 2 or more uncertainty in the stellar wind mass loss rates. We may ask ourselves if stellar rotation is one of the keys to understand the universe, why so many massive stars are binary components and why binaries are ignored or are considered as the poor cousins by some people? And finally, do ultra luminous X-ray sources harbor an intermediate mass black hole with a mass of the order of 1000 M0?