Optimizing Bone Scaffold Porosity Distributions

Dvina Valainis; Kaushik Bhattacharya; Martijn van Griensven; Patrick Dondl; Patrina S.P. Poh

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Optimizing Bone Scaffold Porosity Distributions

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arxiv 1809.08179 v1 pith:S6KKVY2F submitted 2018-09-21 q-bio.TO

Patrina S.P. Poh , Dvina Valainis , Kaushik Bhattacharya , Martijn van Griensven , Patrick Dondl This is my paper · ORCID

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keywords scaffoldbonemechanicalmodelpolymerporosityregenerationstiffness

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We consider a simple one-dimensional time-dependent model for bone regeneration in the presence of a bio-resorbable polymer scaffold. Within the framework of the model, we optimize the effective mechanical stiffness of the polymer scaffold together with the regenerated bone matrix. The result of the optimization procedure is a scaffold porosity distribution which maximizes the stiffness of the scaffold-bone system over the regeneration time, such that the propensity for mechanical failure is reduced.

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