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Cell types and ontologies of the Human Cell Atlas

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arxiv 2106.14443 v1 pith:KSDX25RJ submitted 2021-06-28 q-bio.CB

classification q-bio.CB
keywords celltypeseffortshumanontologyacceleratedacrossadvance
verification ladder T0 review T1 audit T2 compute T3 formal
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Massive single-cell profiling efforts have accelerated our discovery of the cellular composition of the human body, while at the same time raising the need to formalise this new knowledge. Here, we review current cell ontology efforts to harmonise and integrate different sources of annotations of cell types and states. We illustrate with examples how a unified ontology can consolidate and advance our understanding of cell types across scientific communities and biological domains.

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