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Convergence of Free Boundaries in the Incompressible Limit of Tumor Growth Models
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abstract
We investigate the general Porous Medium Equations with drift and source terms that model tumor growth. Incompressible limit of such models has been well-studied in the literature, where convergence of the density and pressure variables are established, while it remains unclear whether the free boundaries of the solutions exhibit convergence as well. In this paper, we provide an affirmative result by showing that the free boundaries converge in the Hausdorff distance in the incompressible limit. To achieve this, we quantify the relation between the free boundary motion and spatial average of the pressure, and establish a uniform-in-$m$ strict expansion property of the pressure supports. As a corollary, we derive upper bounds for the Hausdorff dimensions of the free boundaries and show that the limiting free boundary has finite $(d-1)$-dimensional Hausdorff measure.
Forward citations
Cited by 2 Pith papers
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On the incompressible limit of Keller-Segel system with volume-filling effects
For the volume-filling Keller-Segel system, the incompressible limit is a Hele-Shaw free-boundary problem for K>1 and a hyperbolic Keller-Segel system for K≤1.
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Hele-Shaw limit of chemotaxis-Navier-Stokes flows
For the chemotaxis-Navier-Stokes system with porous medium diffusion, as m→∞ the solutions converge to a Hele-Shaw free boundary problem whose pressure satisfies the complementarity relation P∞(ΔP∞ − ∇·(χ(c∞)∇c∞))=0.
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