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Paper Citation Record · LEDGER

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3

As of 9 August 2026, this Paper Citation Record lists 28 of 28 outbound references and 0 inbound Pith citation observations for arXiv:2505.21873.

A citation records a reference. It does not transfer a finding from one paper to another.

pith.paper-citation-record.v1
2505.21873 v1

Coverage vector

measured 28 of 28 reference resolution

Typed states for the displayed outbound observations.

Source: paper_references, paper_reference_links, observed 2026-08-07T13:25:01.885819Z

measured 28 of 28 standing notices

One-hop event checks from named stored sources.

Source: scholarly_work_events, retraction_status_cache, observed 2026-08-09T06:31:02.800959+00:00

measured 0 of 0 inbound itemization

Pith citing papers itemized under the disclosed page cap.

Source: paper_references, paper_reference_links

measured 0 of 1 external citation measurements

A source-named dated measurement, never combined with another source.

Source: cited_works

Reference resolution

28 of 28 outbound references displayed

  • verified exact0
  • verified fuzzy19
  • unresolved9
  • parse uncertain0
  • malformed identifier0
  • metadata mismatch0

External citation measurements

No source-named external measurement is stored.

Outbound references

Observation c0c0ed42-b8ee-4ee0-a781-f980ecbb4066 · outbound

This paper cites Protein complex prediction with alphafold-multimer.biorxiv, pages 2021–10, 2021.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Protein complex prediction with alphafold-multimer.biorxiv, pages 2021–10, 2021

Reference 1

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:05.529349Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:24:59.208860Z digest=sha256:5cf0a67435de4b8cf6315b950b1055774f4ae095d02dac450d20cb1871709d3b

Observation 95f0fc0f-e457-441d-b155-2217fdfd7c42 · outbound

This paper cites Accurate structure prediction of biomolecular interactions with alphafold 3.Nature, 630(8016):493–500, 2024.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Accurate structure prediction of biomolecular interactions with alphafold 3.Nature, 630(8016):493–500, 2024

Reference 2

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.246432Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.246432Z digest=sha256:e0b6ee9b63fcc10a3150e8ca56ff1733eb56373e2ae5e52024222a6773809e41

Observation 99666bd3-e263-4647-9622-e314321570ae · outbound

This paper cites Technical Report of HelixFold3 for Biomolecular Structure Prediction.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Technical Report of HelixFold3 for Biomolecular Structure Prediction

Reference 3

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.309561Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.309561Z digest=sha256:abfa1ff5279ac1bbbd6ab9f5c67e2aedccc3fb28787da2adc3da2d7a6399fc91

Observation 46378dc0-b613-46db-947a-b9356f6b7cbc · outbound

This paper cites De novo design of high-affinity protein binders with AlphaProteo.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 De novo design of high-affinity protein binders with AlphaProteo

Reference 4

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.418009Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.418009Z digest=sha256:e873148e624c13c74a1161ad016a9d68b0171ec8dae6209a7f1bcf8a128cea97

Observation af263063-16c9-4cae-a6e2-e2ffd1b30a43 · outbound

This paper cites Bindcraft: one-shot design of functional protein binders.bioRxiv, pages 2024–09, 2024.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Bindcraft: one-shot design of functional protein binders.bioRxiv, pages 2024–09, 2024

Reference 5

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:05.383304Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:24:59.504793Z digest=sha256:745735d7ab034e614ce0dc4a0ac3ceb553f6b8e4dedaa206dfa8668e40a21f15

Observation 2b2dbcc1-f6c8-432c-9652-19eafdc10a9b · outbound

This paper cites De novo design of protein structure and function with rfdiffusion.Nature, 620(7976):1089–1100, 2023.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 De novo design of protein structure and function with rfdiffusion.Nature, 620(7976):1089–1100, 2023

Reference 6

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.565734Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.565734Z digest=sha256:e3df8a86cf2467fbce5d02e68c434a2db5800c91196c0d9e6331dd68a70c5308

Observation a7728198-2b5e-41c2-bb0a-82787529b114 · outbound

This paper cites Atom level enzyme active site scaffolding using rfdiffusion2.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Atom level enzyme active site scaffolding using rfdiffusion2

Reference 7

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:05.211922Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:24:59.689478Z digest=sha256:cdd59e1bf2063577c0951889d5e119215ed7b9a5623dbd4b4c84ca47e947122f

Observation a65990d6-ce77-41b0-aaad-498b5e8da35d · outbound

This paper cites Learning inverse folding from millions of predicted structures.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Learning inverse folding from millions of predicted structures

Reference 8

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.786140Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.786140Z digest=sha256:97daf02ae43bbef7a1562125d1a298495e97b66391f811d0d619bb1da91d444c

Observation e377236f-339f-46be-87ad-56cdd4949cdb · outbound

This paper cites Robust deep learning–based protein sequence design using proteinmpnn.Science, 378(6615):49–56, 2022.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Robust deep learning–based protein sequence design using proteinmpnn.Science, 378(6615):49–56, 2022

Reference 9

Resolution
unresolved
no resolver link, observed 2026-08-07T13:24:59.900557Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:24:59.900557Z digest=sha256:2f4d949fd776b013da44b1c3e167952ba271aee7a872a556f0e75d7dcf85d5de

Observation 7959c2b5-b888-47cf-a1d0-a7da8b8380b9 · outbound

This paper cites The foldx web server: an online force field.Nucleic acids research, 33(suppl_2):W382–W388, 2005.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 The foldx web server: an online force field.Nucleic acids research, 33(suppl_2):W382–W388, 2005

Reference 10

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:05.066756Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:24:59.961471Z digest=sha256:a782173a09b78188cbccaedac5c2b0ed198c5efaa4c5b8be1cceec2b5c3a3cf2

Observation 043018b5-6dc2-495c-9ad3-953caea0aed6 · outbound

This paper cites Prodigy: a web server for predicting the binding affinity of protein–protein complexes.Bioinformatics, 32(23):3676–3678, 2016.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Prodigy: a web server for predicting the binding affinity of protein–protein complexes.Bioinformatics, 32(23):3676–3678, 2016

Reference 11

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.933822Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:00.071816Z digest=sha256:0604bedc345b692e1226ea8826e6a86bff5172601eb214917fa274694d3f68d9

Observation 8758d2f1-0cf4-430d-a8f0-8407e419a225 · outbound

This paper cites Improving de novo protein binder design with deep learning.Nature Communications, 14(1):2625, 2023.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Improving de novo protein binder design with deep learning.Nature Communications, 14(1):2625, 2023

Reference 12

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.782673Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:00.176255Z digest=sha256:32b301ab477b8fa1191b94d8ddf5a53a491abce7c96efd9ff793a42e200cc45e

Observation d93beee5-5c50-4a29-98fd-629b67b1d5d0 · outbound

This paper cites Simulating 500 million years of evolution with a language model.Science, page eads0018, 2025.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Simulating 500 million years of evolution with a language model.Science, page eads0018, 2025

Reference 13

Resolution
unresolved
no resolver link, observed 2026-08-07T13:25:00.292247Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:25:00.292247Z digest=sha256:badd6a9c81d8b9b56b27cf7bc03cc5ec774dd0d21e6ceaf6e34f904ddd15729b

Observation 93dd5d3c-55ff-4fa8-a044-4abfce7b0748 · outbound

This paper cites Design of protein-binding proteins from the target structure alone.Nature, 605(7910):551–560, 2022.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Design of protein-binding proteins from the target structure alone.Nature, 605(7910):551–560, 2022

Reference 14

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.625660Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:00.380172Z digest=sha256:f2ddef6f112147b33aafbf55571b8b5fa54fcd305a0aa6f0c04c19a08c55d192

Observation a482e6dc-606f-4d39-9acf-dd6c338b12cf · outbound

This paper cites Protein data bank (pdb): the single global macromolecular structure archive.Protein crystallography: methods and protocols, pages 627–641, 2017.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Protein data bank (pdb): the single global macromolecular structure archive.Protein crystallography: methods and protocols, pages 627–641, 2017

Reference 15

Resolution
unresolved
no resolver link, observed 2026-08-07T13:25:00.483904Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:25:00.483904Z digest=sha256:5526366ff7fcbfb4ca45ad9718c863b5b38fb0429e6c9538c66d924bb7558e04

Observation d82560fe-5bc6-43f5-8b51-73e61527de7a · outbound

This paper cites Evaluation of alphafold 3’s protein–protein complexes for predicting binding free energy changes upon mutation.Journal of Chemical Information and Modeling, 64(16):6676–6683, 2024.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Evaluation of alphafold 3’s protein–protein complexes for predicting binding free energy changes upon mutation.Journal of Chemical Information and Modeling, 64(16):6676–6683, 2024

Reference 16

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.480896Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:00.570033Z digest=sha256:7ff2f8a48423ba1b634627a3843c5f25181caf416620f22f41020ab1bd2131a5

Observation 75d4b4f5-886c-4339-97ba-5af1d15cb182 · outbound

This paper cites Implementing and assessing an alchemical method for calculating protein–protein binding free energy.Journal of chemical theory and computation, 17(4):2457–2464, 2021.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Implementing and assessing an alchemical method for calculating protein–protein binding free energy.Journal of chemical theory and computation, 17(4):2457–2464, 2021

Reference 17

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.306135Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:00.680763Z digest=sha256:bf6580606d3286ebde8319c68466fa0e149d4241234f6620bb5cfa6efd554cac

Observation 91039a53-5bc2-4fe9-a420-35369d4e91c4 · outbound

This paper cites Assessment of software methods for estimating protein-protein relative binding affinities.PLoS One, 15(12):e0240573, 2020.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Assessment of software methods for estimating protein-protein relative binding affinities.PLoS One, 15(12):e0240573, 2020

Reference 18

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.149242Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:00.777704Z digest=sha256:037aacd98ff661a7c28c73faa31b3fca921fa65238a66cd9a32f09b0522569f9

Observation dafcce08-2111-44b0-bfc9-f326c2fb84f7 · outbound

This paper cites Ab-bind: antibody binding mutational database for computational affinity predictions.Protein Science, 25(2):393–409, 2016.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Ab-bind: antibody binding mutational database for computational affinity predictions.Protein Science, 25(2):393–409, 2016

Reference 19

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:04.031375Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:00.881330Z digest=sha256:d0915ee99ce20002a743eeb47743670b63964aa4e528badb51396a98b26b410b

Observation 8fa354da-1f0b-4201-8f93-3d111cb8273d · outbound

This paper cites Structural and biophysical studies of the human il-7/il-7rα complex.Structure, 17(1):54–65, 2009.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Structural and biophysical studies of the human il-7/il-7rα complex.Structure, 17(1):54–65, 2009

Reference 20

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:03.813132Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:00.985327Z digest=sha256:347790f0d5f83be4d560c6901276f994d93e6e3e011445a68ec368ce48545dc3

Observation 6027761e-15c3-43e1-b679-ccac8773986f · outbound

This paper cites Structural insight into how bacteria prevent interference between multiple divergent type iv secretion systems.MBio, 6(6):10–1128, 2015.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Structural insight into how bacteria prevent interference between multiple divergent type iv secretion systems.MBio, 6(6):10–1128, 2015

Reference 21

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:03.617586Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:01.114981Z digest=sha256:0e5d4fc9a3c164c8944e5774e7bde27bd2b3a04f9704a0fab463a454e67615e4

Observation 2b283110-37d4-47b3-af17-5a2006ab9bdb · outbound

This paper cites Crystal structure of nerve growth factor in complex with the ligand-binding domain of the trka receptor.Nature, 401(6749):184–188, 1999.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Crystal structure of nerve growth factor in complex with the ligand-binding domain of the trka receptor.Nature, 401(6749):184–188, 1999

Reference 22

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:03.398934Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:01.225897Z digest=sha256:b37b8b7069a0a293ba17c4c306a9deaefe546dabc76dd01ae62d416d149d06a4

Observation 19af8a04-effb-446d-8d06-2a511b96cdaf · outbound

This paper cites Higher-resolution structure of the human insulin receptor ectodomain: multi-modal inclusion of the insert domain.Structure, 24(3):469–476, 2016.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Higher-resolution structure of the human insulin receptor ectodomain: multi-modal inclusion of the insert domain.Structure, 24(3):469–476, 2016

Reference 23

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:03.182896Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:01.323500Z digest=sha256:51b1cf5e09372cf562e3f475d822f98a4c7272949fa2af2d9b00dbc292416bd0

Observation 581da583-e45d-48d8-8f94-8118101bd9cd · outbound

This paper cites Crystal structures of two fgf-fgfr complexes reveal the determinants of ligand-receptor specificity.Cell, 101(4):413–424, 2000.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Crystal structures of two fgf-fgfr complexes reveal the determinants of ligand-receptor specificity.Cell, 101(4):413–424, 2000

Reference 24

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:02.907945Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:01.458861Z digest=sha256:76bb2ae0443987b61ce004f2b2cca78d2b736513473c1e2301922496359dccd3

Observation 02d532cc-eed6-4975-aef1-bb837464db1e · outbound

This paper cites Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex

Reference 25

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:02.690388Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:01.545403Z digest=sha256:f196e2d0e454d86b5834299961381b019cf665864ac49df1e8964bf49e6752cb

Observation f38fd8c2-7608-48e4-8728-0065aaa07db3 · outbound

This paper cites Improved prediction of protein-protein interactions using alphafold2.Nature communications, 13(1):1265, 2022.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Improved prediction of protein-protein interactions using alphafold2.Nature communications, 13(1):1265, 2022

Reference 26

Resolution
unresolved
no resolver link, observed 2026-08-07T13:25:01.630279Z

Source-reported events for the cited work

Unavailable: canonical work link unavailable.

source=pdf_text observed=2026-08-07T13:25:01.630279Z digest=sha256:f6e3317c8ad3cf2e08b9f57cd247ec0e7de8983083f2b90c2bc1f51bbf469b2c

Observation a735ea7a-3f2e-47c9-b842-941510715375 · outbound

This paper cites Enhanced protein-protein interaction discovery via alphafold-multimer.bioRxiv, pages 2024–02, 2024.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Enhanced protein-protein interaction discovery via alphafold-multimer.bioRxiv, pages 2024–02, 2024

Reference 27

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:02.454214Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:01.779396Z digest=sha256:ab9412fd083a99c6ddaa2a91b7331324721e40e12a50a9e390d876ff907f0ca1

Observation 38fced04-eed5-41c5-b3bb-7d3bdb2e2727 · outbound

This paper cites Protein modeling and structure-based drug design.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3 Protein modeling and structure-based drug design

Reference 28

Resolution
verified fuzzy
raw_fallback, observed 2026-08-07T13:25:02.199951Z

Source-reported events for the cited work

No event found in the named queried sources as of 2026-08-09T06:31:02.800959+00:00.

source=pdf_text observed=2026-08-07T13:25:01.885819Z digest=sha256:2873ddc17589f6a7fa514e6ea2621b648858e46e9a1c65a4ac0e4253e5b80bb8

Pith citing papers

No inbound Pith citation observations are available.