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REVIEW 4 major objections 5 minor 59 references

New tissue engineered scaffolds for rotator cuff tendon-bone interface regeneration

T0 review · 4 major / 5 minor · reviewed 2026-08-07 · deepseek-v4-flash

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Pith's one-line read The paper argues that tissue-engineered scaffolds, especially gradient biomimetic scaffolds, are the most promising route to regenerate the rotator cuff's tendon-bone interface instead of letting it heal with scar tissue.

desk verdict A readable but unoriginal narrative review whose 'significant leap' claim for gradient scaffolds is unsupported by the evidence it cites, with one unambiguous citation error that should be fixed before publication. read the letter →

arxiv 2506.12236 v1 pith:HNVVVKAT submitted 2025-06-13 q-bio.TO

Ting Zhang , Jianying Zhang This is my paper · ORCID
classification q-bio.TO
keywords rotatorcufftendon-boneinterfacetissueengineeringgradientbiomimeticscaffolddesignfibrocartilageregenerationretearprevention
verification ladder T0 review T1 audit T2 compute T3 formal

The pith

A machine-rendered reading of the paper's core claim, the machinery that carries it, and where it could break.

The reading

The paper argues that tissue-engineered scaffolds, especially gradient biomimetic scaffolds, are the most promising route to regenerate the rotator cuff's tendon-bone interface (TBI) instead of letting it heal with scar tissue. Rotator cuff repairs fail because surgery restores only the anatomical position of the tendon, not the native four-layer structure—tendon, uncalcified fibrocartilage, calcified fibrocartilage, and bone—that normally spreads mechanical stress. The review contends that scaffolds which replicate this continuous gradient can improve load distribution, support stem-cell differentiation into the right cell types at the right locations, and reduce fibrous scar formation. If this holds, such scaffolds could lower the 20–94% re-tear rates reported after rotator cuff repair. The paper's case is built from animal-model studies, so its clinical promise depends on those results transferring to human patients.

What carries the argument

The load-bearing object is the four-layer tendon-bone interface and the gradient biomimetic scaffold designed to copy it. The natural TBI is a continuous transition from tendon through uncalcified and calcified fibrocartilage to bone, with graded fibre alignment and matrix composition. Gradient biomimetic scaffolds are fabricated so that structure and bioactivity change gradually along the same axis, using techniques such as electrospinning, photothermal welding, 3D bioprinting, and salt immersion. This gradient design is what carries the argument: it is supposed to distribute mechanical load smoothly across the interface, prevent stress concentration, and present each stem-cell population with the signals needed to form the appropriate tissue, thereby avoiding the scar-tissue healing that leads to re-tear.

What would settle it

A randomized clinical trial in which a gradient biomimetic scaffold is added to standard rotator cuff repair and compared with repair alone would settle the claim: if retear rates and structural healing on MRI are no better with the scaffold, the central argument fails.

Watch

Extended reading notes

Core claim

The central claim is that the reason rotator cuff repairs commonly re-tear is not surgical technique but the failure to restore the TBI's native gradient architecture, and that scaffold design can fix this. Single-layer scaffolds provide simple support and a uniform biochemical signal, but they cannot serve the different microenvironments needed by tendon cells, chondrocytes, and osteoblasts at once. Multilayer integrated scaffolds improve on this by giving each side of the interface its own environment, but their layer boundaries are abrupt, unlike the gradual transitions of healthy tissue. Gradient biomimetic scaffolds—built by electrospinning, 3D printing, freeze-drying, or related methods—reproduce the continuous spatial change in fibre alignment, mineral content, and bioactive signals. The paper contends that this fidelity to the native gradient is what makes them a qualitative advance, delivering seamless structure, better load transfer, and coordinated stem-cell differentiation toward tendon, cartilage, and bone.

Load-bearing premise

The argument assumes that healing outcomes in small-animal rotator cuff models, mainly rats and New Zealand rabbits, translate to human shoulder repair, so if animal healing does not predict human healing the case for gradient scaffolds loses most of its force.

Editorial extensions

If this is right

  • If gradient biomimetic scaffolds restore the four-layer structure, rotator cuff repairs could heal with a functional enthesis rather than scar tissue, lowering reported re-tear rates of 20–94%.
  • Scaffolds can double as delivery systems, releasing growth factors, kartogenin, exosomes, or metal ions in a spatially graded pattern to steer stem-cell differentiation at each end of the interface.
  • Gradient scaffolds could reduce stress concentration at the repair site, improving biomechanical strength of the supraspinatus tendon–humerus connection, as seen in electrospun-fibre animal studies.
  • The success of these designs would shift clinical practice from purely mechanical repair toward biological augmentation at the time of surgery.

Reading between the lines

Editorial extensions of the paper, not claims the author makes directly.

  • The hierarchy the review implies—gradient scaffolds outperforming multilayer, and multilayer outperforming single-layer—could be tested head-to-head in the same animal model using matched materials; the review does not provide such a direct comparison.
  • If gradient fidelity is the active ingredient, then measurable scaffold properties such as the slope of mineral-content change or fibre-alignment transition should correlate with healing outcomes; this is a testable extension the authors do not pursue.
  • The review's reliance on rabbit and rat models suggests that the next decisive step is a large-animal or human trial comparing a gradient scaffold with standard repair and using retear as the endpoint.
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Editorial analysis

A structured set of objections, weighed in public.

Desk editor's note, referee report, and a circularity audit.

Referee Report

4 major / 5 minor

Summary. This manuscript is a narrative review of tissue-engineered scaffolds for rotator cuff tendon-bone interface (TBI) regeneration. It classifies scaffolds into single-layer, multilayer integrated, and gradient biomimetic types, summarizes representative studies for each category, and concludes that multilayer and especially gradient scaffolds are a 'significant leap' that can replicate the native TBI gradient and improve healing outcomes. The review also discusses scaffold material properties, fabrication methods, and future directions.

Significance. If the central advocacy for gradient biomimetic scaffolds is well supported, the review could serve as a useful orientation for researchers and clinicians selecting scaffold designs for rotator cuff repair. The compilation of recent studies, particularly the coverage of electrospinning, 3D printing, and bio-ink approaches in Section 4, is timely. However, as a review, its value depends on accurate citation and on the strength of the evidence adduced for its main claim; the paper currently has neither fully in place.

major comments (4)
  1. [Section 2] The sentence describing KGN-loaded GelMA hydrogel scaffolds states 'Chenglong Huang et al. [35] demonstrated ... [27].' Reference [27] is Lv et al., which concerns a PVA/nano-hydroxyapatite composite hydrogel for ACL reconstruction, not a GelMA scaffold. The correct citation for the GelMA study is reference [35], already cited in the same sentence. This citation error leaves the sentence without valid support and must be corrected.
  2. [Section 5] The concluding claim that multilayer integrated scaffolds, 'especially gradient biomimetic scaffolds, represent a significant leap in biomaterial design' and provide 'improved load distribution' is not supported by the evidence in Section 4. No cited study directly compares a gradient scaffold with a single-layer or multilayer scaffold matched for material and biofactor content, and none of the cited studies measures load distribution at the TBI. The assertion of improved load distribution is mechanistic speculation rather than an observed outcome. The review should either temper this claim to reflect the lack of comparative evidence or add a discussion of the specific studies that support it.
  3. [Introduction, paragraph 4] The statement 'By mimicking the mechanical gradient environment of TBI, the scaffold achieves optimized mechanical distribution... [16]' cites reference [16], which is Gentile et al., a study on titanium-coated polypropylene mesh for breast reconstruction. This reference is not relevant to tendon-bone scaffolds and does not support the claim. The citation should be replaced with an appropriate scaffold-related reference, or the sentence should be revised.
  4. [Section 4] The review extrapolates from small-animal and rabbit studies to clinical application without discussing species differences in tendon-bone healing or the well-known challenges of translating animal results to humans. For a review that repeatedly frames scaffolds as having clinical potential, this omission is load-bearing for the translational claim. A sentence acknowledging the limited predictive value of animal models for human rotator cuff repair would strengthen the review's balance.
minor comments (5)
  1. [Section 1] The classification of scaffolds into 'biologically derived, inorganic, and organic synthetic' is fine, but the subsequent division into 'single-layer, multilayer integrated, and gradient scaffolds' creates a somewhat overlapping taxonomy; for instance, a gradient scaffold can also be considered a multilayer scaffold. Clarifying the relationship between these classifications would improve readability.
  2. [Section 4] The phrase 'TGF-β/PVA supplemented in the tendon region' is ambiguous; it should specify whether TGF-β refers to a specific isoform (e.g., TGF-β3) and whether PVA is the carrier or a separate component.
  3. [Abstract] The abstract contains several grammatical and typographical issues, such as 'va rious' in the full text and inconsistent comma usage. The manuscript would benefit from a careful language edit.
  4. [References] Reference formatting is inconsistent: some entries have stray spaces (e.g., reference 1), and reference 12 has '14008-,' with a trailing comma. These should be standardized to the journal's style.
  5. [Section 2] The sentence 'Recently, research has found that exosomes are nanoscale extracellular vesicles...' does not mention the source of the exosomes or the specific context of TBI healing, making it somewhat disconnected from the subsequent discussion of GelMA scaffolds.

Circularity Check

0 steps flagged · score 0.0 of 10

No circularity: this narrative review's claims are summaries of external primary literature, and the authors' self-citations are non-load-bearing background statements.

full rationale

The paper is a narrative review of tissue-engineered scaffolds for rotator cuff tendon-bone interface regeneration. It contains no equations, no fitted parameters, and no derivation chain; its Section 5 conclusion that multilayer integrated scaffolds, especially gradient biomimetic scaffolds, 'represent a significant leap in biomaterial design' is an interpretive summary of separately cited primary studies (refs 54-59), not a prediction generated from the authors' own inputs. The only self-citations are references [12]-[15], used to support background statements such as 'Several of our studies have demonstrated the role of kartogenin (KGN) and PRP in promoting tendon bone healing [12-14]' and an observation on bone marrow stimulation; these statements are not load-bearing for the review's comparative advocacy of gradient scaffolds. No uniqueness theorem, no ansatz, and no renamed empirical pattern is imported from the authors' prior work. The skeptical concern that the 'significant leap' claim is under-evidenced, because no head-to-head gradient-versus-single-layer comparison is described and no load distribution is measured, is a question of evidential support rather than circularity. The review itself concedes in Section 4 that gradient scaffolds 'still require further exploration.' The argument is self-contained as a literature summary, so the circularity score is 0.

Assumptions & free parameters 0 free parameters · 3 assumptions · 0 invented entities

This is a narrative review with no new calculations or measurements. The scientific content rests on cited primary literature. The main external assumptions are that animal models are predictive of human healing, that the four-layer interface is the correct target, and that the cited studies are accurately represented.

assumptions (3)
  • domain assumption The native four-layer tendon-bone interface (tendon, uncalcified fibrocartilage, calcified fibrocartilage, bone) is the correct architectural target for regeneration.
    Invoked in the Introduction and throughout; if this target structure is not the clinically relevant goal, the rationale for gradient scaffolds weakens.
  • domain assumption Results from small-animal and rabbit rotator cuff models are predictive of human rotator cuff healing.
    The review generalizes from studies in New Zealand rabbits, rats, and other animal models in Sections 2 to 4 to clinical application in rotator cuff repair.
  • domain assumption The cited primary studies are accurately reported and otherwise valid.
    The review conducts no experiments; its conclusions depend entirely on the validity and faithful reporting of the cited papers, including the source of the KGN-loaded GelMA claim.

how reviews work

0 comments
Cite this review

Pith. "Pith review of New tissue engineered scaffolds for rotator cuff tendon-bone interface regeneration." pith.science (2026). https://pith.science/paper/HNVVVKAT

@misc{pith2026250612236,
  author       = {Pith},
  title        = {Pith review of: New tissue engineered scaffolds for rotator cuff tendon-bone interface regeneration},
  year         = {2026},
  howpublished = {\url{https://pith.science/paper/HNVVVKAT}},
  note         = {Machine review of arXiv:2506.12236}
}
read the original abstract

Healing of Tendon-bone interface(TBI) injuries is slow and is often repaired with scar tissue formation that compromises normal function. Despite the increasing maturity of surgical techniques, re-tearing of the rotator cuff after surgery remains common. The main reason for this issue is that the original structure of the rotator cuff at the TBI area is difficult to fully restore after surgery, and anatomical healing of the rotator cuff TBI is challenging to achieve solely through surgery. With the advancement of tissue engineering technology, more and more basic researchers and clinical surgeons are recognizing the enormous potential of tissue engineering in promoting TBI healing. Growing research evidence indicates that tissue engineering technology not only effectively promotes repairing and remodeling of the TBI but also reduces the formation of fibrous vascular scar tissue, leading to more orderly tissue reconstruction. The core of tissue engineering technology approaches lies in combining the use of various scaffolds, cells and bioactive molecules to simulate the natural environment of TBI healing, achieving optimal therapeutic outcomes. In this review, we will systematically summarize and highlight recent progress in the application of tissue engineering on TBI regeneration, particularly focusing on advancements in novel scaffolds and their role and potential in promoting healing of the TBI of rotator cuff, providing valuable references for clinical application and research.

Discussion (0). Continue with ORCID to comment.

Reference graph

Works this paper leans on

59 extracted references · 58 canonical work pages

  1. [27]

    Kartogenin-Loaded Polyvinyl Alcohol/Nano -Hydroxyapatite Composite Hydrogel Promotes Tendon -Bone Healing in Rabbits after Anter ior Cruciate Ligament Reconstruction

    Lv, H.; L iu, Y .; Lu, D.; Wang, Y . Kartogenin-Loaded Polyvinyl Alcohol/Nano -Hydroxyapatite Composite Hydrogel Promotes Tendon -Bone Healing in Rabbits after Anter ior Cruciate Ligament Reconstruction. Journal of Biomedical Materials Research - Part A 2024, 112, 180–192, doi:10.1002/jbm.a.37605

    work page doi:10.1002/jbm.a.37605 2024

  2. [35]

    Effect of Kartogenin-Loaded Gelatin Methacryloyl Hydrogel Scaffold with Bone Marrow Stimulation for Enthesis Healing in Rotator Cuff Repair

    Huang, C.; Zhang, X.; Luo, H.; Pan, J.; Cui, W.; Cheng, B.; Zhao, S.; Chen, G. Effect of Kartogenin-Loaded Gelatin Methacryloyl Hydrogel Scaffold with Bone Marrow Stimulation for Enthesis Healing in Rotator Cuff Repair. J Shoulder Elbow Surg 2021, 30, 544 –553, doi:10.1016/j.jse.2020.06.013

    work page doi:10.1016/j.jse.2020.06.013 2021

  3. [16]

    Titanium-Coated Polypropylene Mesh as Innovative Bioactive Material in Conservatives Mastectomies and Pre-Pectoral Breast Reconstruction

    Gentile, P .; Bernini, M.; Orzalesi, L.; Sordi, S.; Meattini, I.; Lessi, F.; Kothari, A.; Calabrese, C. Titanium-Coated Polypropylene Mesh as Innovative Bioactive Material in Conservatives Mastectomies and Pre-Pectoral Breast Reconstruction. Bioact Mater 2021, 6, 4640–4653, doi:10.1016/j.bioactmat.2021.05.002

    work page doi:10.1016/j.bioactmat.2021.05.002 2021

  4. [1]

    Evaluation of the Reliability of Physical Examination and MRI in the Diagnosis of Rotator Cuff Injuries

    Zhang, T.; Shi, C.; Li, G.; Li, B.; Zhang, L. Evaluation of the Reliability of Physical Examination and MRI in the Diagnosis of Rotator Cuff Injuries. Guangdong Medical Journal. 2016, 37, 1968–1970, doi:10.13820/j.cnki.gdyx.2016.13.011

    work page doi:10.13820/j.cnki.gdyx.2016.13.011 2016

  5. [2]

    Diagnostic value of different physical examinations of the shoulder joint for supraspinatus tendon tears in rotator cuff injuries

    Zhang, T.; Shi, C.; Li, B. Diagnostic value of different physical examinations of the shoulder joint for supraspinatus tendon tears in rotator cuff injuries. Guangdong Medical Journal 2014, 35, 84–85, doi:10.13820/j.cnki.gdyx.2014.01.039

    work page doi:10.13820/j.cnki.gdyx.2014.01.039 2014

  6. [3]

    Which Method of Rotator Cuff Repair Leads to the Highest Rate of Structural Healing? A Systematic Review

    Duquin, T.R.; Buyea, C.; Bisson, L.J. Which Method of Rotator Cuff Repair Leads to the Highest Rate of Structural Healing? A Systematic Review. Am J Sports Med 2010, 38, 835–841, doi:10.1177/0363546509359679

    work page doi:10.1177/0363546509359679 2010

  7. [4]

    Factors Predicting Rotator Cuff Retears: An Analysis of 1000 Consecutive Rotator Cuff Repairs

    Le, B.T.N.; Wu, X.L.; Lam, P .H.; Murrell, G.A.C. Factors Predicting Rotator Cuff Retears: An Analysis of 1000 Consecutive Rotator Cuff Repairs. Am J Sports Med 2014, 42, 1134–1142, doi:10.1177/0363546514525336

    work page doi:10.1177/0363546514525336 2014

  8. [5]

    A Systematic Review and Pooled Analysis of the Prevalence of Rotator Cuff Disease with Increasing Age

    Teunis, T.; Lubberts, B.; Reilly, B.T.; Ring, D. A Systematic Review and Pooled Analysis of the Prevalence of Rotator Cuff Disease with Increasing Age. J Shoulder Elbow Surg 2014, 23, 1913–1921, doi:10.1016/j.jse.2014.08.001

    work page doi:10.1016/j.jse.2014.08.001 2014

Show all 59 references
  1. [6]

    The Microstructure and Micromechanics of the Tendon-Bone Insertion

    Rossetti, L.; Kuntz, L.A.; Kunold, E.; Schock, J.; Müller, K.W.; Grabmayr, H.; Stolberg-Stolberg, J.; Pfeiffer, F.; Sieber, S.A.; Burgkart, R.; et al. The Microstructure and Micromechanics of the Tendon-Bone Insertion. Nat Mater 2017, 16, 664–670, doi:10.1038/nmat4863

    2017 doi

  2. [7]

    Characterization of Zinc and Calcium Spatial Distribution at the Fibrocartilage of Rabbit Patella-Patellar Tendon Complex: A Synchrotron Radiation Micro X-Ray Fluorescence Study

    Chen, C.; Wang, Z.; Zheng, C.; Wu, T.; Cao, Y .; Jianzhong, H.; Zheng, Y .; Lu, H. Characterization of Zinc and Calcium Spatial Distribution at the Fibrocartilage of Rabbit Patella-Patellar Tendon Complex: A Synchrotron Radiation Micro X-Ray Fluorescence Study. Journal of Orth...

    2014 doi

  3. [8]

    The Tendon -to-Bone Attachment: Unification through Disarray

    Genin, G.M.; Thomopoulos, S. The Tendon -to-Bone Attachment: Unification through Disarray. Nat Mater 2017, 16, 607–608, doi:10.1038/nmat4906

    2017 doi

  4. [9]

    A New Tissue Engineering Strategy to Promote Tendon-Bone Healing: Regu lation of Osteogenic and Chondrogenic Differentiation of Tendon-Derived Stem Cells

    Shen, S.; Lin, Y .; Sun, J.; Liu, Y .; Chen, Y .; Lu, J. A New Tissue Engineering Strategy to Promote Tendon-Bone Healing: Regu lation of Osteogenic and Chondrogenic Differentiation of Tendon-Derived Stem Cells. Orthop Surg 2024, 16, 2311–2325, doi:10.1111/os.14152

    2024 doi

  5. [10]

    Pluripotent Stem Cell -Based Cell Therapy-Promise and Challenges

    Yamanaka, S. Pluripotent Stem Cell -Based Cell Therapy-Promise and Challenges. Cell Stem Cell 2020, 27, 523–531, doi:10.1016/j.stem.2020.09.014

    2020 doi

  6. [11]

    Strategies to Engineer Tendon/Ligament-to-Bone Interface: Biomaterials, Cells and Growth Factors

    Font Tellado, S.; Balmayor, E.R.; Van Gr iensven, M. Strategies to Engineer Tendon/Ligament-to-Bone Interface: Biomaterials, Cells and Growth Factors. Adv Drug Deliv Rev 2015, 94, 126–140, doi:10.1016/j.addr.2015.03.004

    2015 doi

  7. [12]

    Kartogenin Induces Cartilage-like Tissue Formation in Tendon-Bone Junction

    Zhang, J.; Wang, J.H.-C. Kartogenin Induces Cartilage-like Tissue Formation in Tendon-Bone Junction. Bone Res 2014, 2, 14008-, doi:10.1038/boneres.2014.8

    2014 doi

  8. [13]

    Kartogenin with PRP Promotes the Formation of Fibrocartila ge Zone in the Tendon-Bone Interface

    Zhou, Y .; Zhang, J.; Yang, J.; Narava, M.; Zhao, G.; Yuan, T.; Wu, H.; Zheng, N.; Hogan, M .V.; Wang, J.H.-C. Kartogenin with PRP Promotes the Formation of Fibrocartila ge Zone in the Tendon-Bone Interface. J Tissue Eng Regen Med 2017, 11, 3445 –3456, doi:10.1002/term.2258. 8

    2017 doi

  9. [14]

    Zhang, J.; Yuan, T.; Zheng, N.; Zhou, Y .; Hogan, M.V.; Wang, J.H. -C. The Combined Use of Kartogenin and Platelet -Rich Plasma Promotes Fibrocartila ge Formation in the Wounded Rat Achilles Tendon Entheses. Bone Joint Res 2017, 6, 231 –244, doi:10.1302/2046-3758.64.BJR-2017-0268.R1

    2017 doi

  10. [15]

    Study on the observation of the short-term effect of the deboned cortex freshen ing and marrow -stimulating technique after rotator cuff injury repair

    Zhang, T.; Sun, X.; Deng, Y .; Gao, L. Study on the observation of the short-term effect of the deboned cortex freshen ing and marrow -stimulating technique after rotator cuff injury repair. Chongqing Medicine 2019, 49, 2507 –2510, doi:10.3969/j.issn.1671-8348.2020.15.022

    2019

  11. [17]

    Biomimetic Gradient Scaffolds for the Tissue Engineering and Regeneration of Rotator Cuff Enthesis

    Chen, Y .; Li, Y .; Zhu, W.; Liu, Q. Biomimetic Gradient Scaffolds for the Tissue Engineering and Regeneration of Rotator Cuff Enthesis. Biofabrication 2024, 16, doi:10.1088/1758-5090/ad467d

    2024 doi

  12. [18]

    Biological Approaches to the Repair and Regeneration of the Rotator Cuff Tendon-Bone Enthesis: A Literature Review

    Abdalla, A.A.; Pendegrass, C.J. Biological Approaches to the Repair and Regeneration of the Rotator Cuff Tendon-Bone Enthesis: A Literature Review. Biomater Transl 2023, 4, 85–103, doi:10.12336/biomatertransl.2023.02.004

    2023 doi

  13. [19]

    Structure, Ingredient, and Function -Based Bio mimetic Scaffolds for Accelerated Healing of Tendon-Bone Interface

    Dong, Y .; Li, J.; Jiang, Q.; He, S.; Wang, B.; Yi, Q.; Cheng, X.; Gao, X.; Bai, Y . Structure, Ingredient, and Function -Based Bio mimetic Scaffolds for Accelerated Healing of Tendon-Bone Interface. Journal of Orthopaedic Translation 2024, 48, 70 –88, doi:10.1016/j.jot.2024.07.007

    2024 doi

  14. [20]

    Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon‐to‐Bone Healing: A Large Animal Stud y and Short‐Term Outcome of a Clinical Trial

    Kang, Y .; Wang, L.; Zhang, S.; Liu, B.; Gao, H.; Jin, H.; Xiao, L.; Zhang, G.; Li, Y .; Jiang, J.; et al. Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon‐to‐Bone Healing: A Large Animal Stud y and Short‐Term Outcome of a Clinical Trial. Advanced Science 2024, ...

    2024 doi

  15. [21]

    -C.; Jeon, H.; Han, H

    Park, S.; Rahaman, K.A.; Kim, Y . -C.; Jeon, H.; Han, H. -S. Fostering Tissue Engineering and Regenerative Medicine to Treat Musculoskeletal Dis orders in Bone and Muscle. Bioactive Materials 2024, 40, 345–365, doi:10.1016/j.bioactmat.2024.06.022

    2024 doi

  16. [22]

    Saab, M.; Hildebrand, F.; Martel, B.; Blanc hemain, N. Osteoinductive Bone Morphogenic Protein, Collagen Scaffold, Calcium Phosphate Cement, and Magn esium-Based Fixation Enhance Anterior Cruciate Ligament Tendon Graft to Bone Healing In Animal Models: A Systematic Review. Art...

    2023 doi

  17. [23]

    Tendon Stem Cells See ded on Dynamic Chondroitin Sulfate and Chitosan Hydrogel Scaffold with BMP2 Enhance Tendon -to-Bone Healing

    Zhang, Q.; Wen, H.; Liao, G.; Cai, X. Tendon Stem Cells See ded on Dynamic Chondroitin Sulfate and Chitosan Hydrogel Scaffold with BMP2 Enhance Tendon -to-Bone Healing. Heliyon 2024, 10, e25206, doi:10.1016/j.heliyon.2024.e25206

    2024 doi

  18. [24]

    Mechanical and Biological Prop erties of Hydroxyapatite/Tricalcium Phosphate Scaffolds Coated with Poly(Lactic -Co-Glycolic Acid)

    Miao, X.; Tan, D.M.; Li, J.; Xiao, Y .; Crawford, R. Mechanical and Biological Prop erties of Hydroxyapatite/Tricalcium Phosphate Scaffolds Coated with Poly(Lactic -Co-Glycolic Acid). Acta Biomater 2008, 4, 638–645, doi:10.1016/j.actbio.2007.10.006

    2008 doi

  19. [25]

    A Systematic Review of Tissue Engineering Scaffold in Tendon Bone Healing in Vivo

    Mao, Z.; Fan, B.; Wang, X.; Huang, X.; Guan, J.; Sun, Z.; Xu, B.; Yang, M.; Chen, Z.; Jiang, D.; et al. A Systematic Review of Tissue Engineering Scaffold in Tendon Bone Healing in Vivo. Front Bioeng Biotechnol 2021, 9, 621483, doi:10.3389/fbioe.2021.621483

    2021

  20. [26]

    The 3D-Printed PLGA Scaffolds Loaded with Bone Marrow-Derived Mesenchymal Stem Cells 9 Augment the Healing of Rotator Cuff Repai r in the Rabbits

    Chen, P .; Cui, L.; Fu, S.C.; Shen, L.; Zhang, W.; You, T.; Ong, T.-Y .; Liu, Y .; Yung, S.-H.; Jiang, C. The 3D-Printed PLGA Scaffolds Loaded with Bone Marrow-Derived Mesenchymal Stem Cells 9 Augment the Healing of Rotator Cuff Repai r in the Rabbits. Cell Transplant 2020, 29...

    2020 doi

  21. [28]

    Economic Evaluation of a Bioinductive Implant for the Repair of Rotator Cuff Tears Compared with Standard Surgery in Italy

    Rognoni, C.; Nherera, L.M.; Garofalo, R.; Guerra, E.; Longo, U.G.; Taverna, E.; Tarricone, R. Economic Evaluation of a Bioinductive Implant for the Repair of Rotator Cuff Tears Compared with Standard Surgery in Italy. Adv T her 2023, 40, 5271 –5284, doi:10.1007/s12325-023-02686-9

    2023 doi

  22. [29]

    Commercial Extracell ular Matrix Scaffolds for Rotator Cuff Tendon Repair

    Derwin, K.A.; Baker, A.R.; Spragg, R.K.; Leigh, D.R.; Iannotti, J.P . Commercial Extracell ular Matrix Scaffolds for Rotator Cuff Tendon Repair. Biomechanical, Biochemical, and Cellular Properties. J Bone Joint Surg Am 2006, 88, 2665–2672, doi:10.2106/JBJS.E.01307

    2006 doi

  23. [30]

    Development of the Supraspinatus Tendon -to-Bone Insertion: Localized Expression of Extracellular Matrix and Growth Factor Genes

    Galatz, L.; Rothermich, S.; VanderPloeg, K.; Petersen, B.; Sandell, L.; Thom opoulos, S. Development of the Supraspinatus Tendon -to-Bone Insertion: Localized Expression of Extracellular Matrix and Growth Factor Genes. J Orthop Res 2007, 25, 1621 –1628, doi:10.1002/jor.20441

    2007 doi

  24. [31]

    Osteoprotegerin/Bone Morphogenetic Protein 2 Combining with Collagen Sponges on Tendon-Bone Healing in Rabbits

    Wei, B.; Wang, C.; Yan, C.; Tang, B.; Yu, X.; Zhang, H.; Tang, L.; Wang, Q. Osteoprotegerin/Bone Morphogenetic Protein 2 Combining with Collagen Sponges on Tendon-Bone Healing in Rabbits. J Bone Miner Metab 2020, 38, 432 –441, doi:10.1007/s00774-019-01078-w

    2020 doi

  25. [32]

    Biofabrication of Soft Tissue Templates for Engineering the Bone -Ligament Interface

    Harris, E.; Liu, Y .; Cunniffe, G.; Morrissey, D.; Carroll, S.; Mulhall, K.; Kelly, D.J. Biofabrication of Soft Tissue Templates for Engineering the Bone -Ligament Interface. Biotechnol Bioeng 2017, 114, 2400–2411, doi:10.1002/bit.26362

    2017 doi

  26. [33]

    Therapeutic Potential and Mechanisms of Mesenchymal Stem Cell -Derived Exosomes as Bioactive Materials in Tendon –Bone Healing

    Zou, J.; Yang, W.; Cui, W.; Li, C.; Ma, C.; Ji, X.; Hong, J.; Qu, Z.; Chen, J.; Liu, A.; et al. Therapeutic Potential and Mechanisms of Mesenchymal Stem Cell -Derived Exosomes as Bioactive Materials in Tendon –Bone Healing. Journal of Nanobiot echnology 2023, 21, doi:10.1186/s...

    2023 doi

  27. [34]

    Engineered Exosomes: A Promising Strategy for Tendon -Bone Healing

    Qin, B.; Bao, D.; L iu, Y .; Zeng, S.; Deng, K.; Liu, H.; Fu, S. Engineered Exosomes: A Promising Strategy for Tendon -Bone Healing. J Adv Res 2024, 64, 155 –169, doi:10.1016/j.jare.2023.11.011

    2024 doi

  28. [36]

    Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine

    Samsonraj, R.M.; Raghunath, M.; Nurcom be, V.; Hui, J.H.; van Wijnen, A.J.; Cool, S.M. Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine. Stem Cells Transl Me d 2017, 6, 2173 –2185, doi:10.1002/sctm.17-0129

    2017 doi

  29. [37]

    Fabrication of PLLA/β -TCP Nanocomposite Scaffolds with Hierarchical Porosity for Bone Tissue Engineering

    Lou, T.; Wang, X.; Song , G.; Gu, Z.; Yang, Z. Fabrication of PLLA/β -TCP Nanocomposite Scaffolds with Hierarchical Porosity for Bone Tissue Engineering. Int J Biol Macromol 2014, 69, 464–470, doi:10.1016/j.ijbiomac.2014.06.004

    2014 doi

  30. [38]

    A Biodegradable Porous Co mposite Scaffold of PGA/Beta -TCP for Bone Tissue Engineering

    Cao, H.; Kuboyama, N. A Biodegradable Porous Co mposite Scaffold of PGA/Beta -TCP for Bone Tissue Engineering. Bone 2010, 46, 386–395, doi:10.1016/j.bone.2009.09.031. 10

    2010 doi

  31. [39]

    A bFGF -Releasing Silk/PLGA-Based Biohybrid Scaffold for Ligament/Tendon Tissue Engineering Using Me senchymal Progenitor Cells

    Sahoo, S.; Toh, S.L.; Goh, J.C.H. A bFGF -Releasing Silk/PLGA-Based Biohybrid Scaffold for Ligament/Tendon Tissue Engineering Using Me senchymal Progenitor Cells. Biomaterials 2010, 31, 2990–2998, doi:10.1016/j.biomaterials.2010.01.004

    2010 doi

  32. [40]

    Nan ofiber Scaffolds with Gradients in Mineral Content for Spatial Control of Osteogenesis

    Liu, W.; Lipner, J.; Xie, J.; Manning, C.N.; Thomopoulos, S.; Xia, Y . Nan ofiber Scaffolds with Gradients in Mineral Content for Spatial Control of Osteogenesis. ACS Appl Mater Interfaces 2014, 6, 2842–2849, doi:10.1021/am405418g

    2014 doi

  33. [41]

    -P .A.; Kroeze, R

    Vergroesen, P . -P .A.; Kroeze, R. -J.; Helder, M.N.; Smit, T.H. The Use of Poly(L-Lactide-Co-Caprolactone) as a Scaffold for Adipose Stem Cells in Bone Tissue Engineering: A pplication in a Spinal Fusion Model. Macromol Biosci 2011, 11, 722 –730, doi:10.1002/mabi.201000433

    2011 doi

  34. [42]

    Growth Factor Gradients via Microsphere Delivery in Biopolymer Scaffolds for Osteochondral Tissue Engineering

    Wang, X.; Wenk, E.; Zhang, X.; Meinel, L.; Vunjak -Novakovic, G.; Kaplan, D.L. Growth Factor Gradients via Microsphere Delivery in Biopolymer Scaffolds for Osteochondral Tissue Engineering. J Control Release 2009, 134, 81–90, doi:10.1016/j.jconrel.2008.10.021

    2009 doi

  35. [43]

    Scleraxis -Overexpressed Human Em bryonic Stem Cell -Derived Mesenchymal Stem Cells for Tendon Tissue Engineering with Knitted Silk -Collagen Scaffold

    Chen, X.; Yin, Z.; Chen, J.-L.; Liu, H.-H.; Shen, W.-L.; Fang, Z.; Zhu, T.; Ji, J.; Ouyang, H.-W.; Zou, X.-H. Scleraxis -Overexpressed Human Em bryonic Stem Cell -Derived Mesenchymal Stem Cells for Tendon Tissue Engineering with Knitted Silk -Collagen Scaffold. Tissue Eng Part...

    2014

  36. [44]

    Long-Term Effects of Knitted Silk -Collagen Sponge Scaffold on Anterior Cruciate Ligament Reconstruction and Osteoarthritis Prevention

    Shen, W.; Chen, X.; Hu, Y .; Yin, Z.; Zhu, T.; Hu, J.; Chen, J.; Zheng, Z.; Zhang, W.; Ran, J.; et al. Long-Term Effects of Knitted Silk -Collagen Sponge Scaffold on Anterior Cruciate Ligament Reconstruction and Osteoarthritis Prevention. Biomaterials 2014, 35, 8154 –8163, doi...

    2014 doi

  37. [45]

    The Hydroxyapatite Modified 3D Printed Poly L-Lactic Acid Porous Screw in Reconstruction of Anterior Cruciate Ligament of Rabbit Knee Joint: A Histological and Biomechanical Study

    Wang, Y .; Ren, C.; Bi, F.; Li, P .; Tian, K. The Hydroxyapatite Modified 3D Printed Poly L-Lactic Acid Porous Screw in Reconstruction of Anterior Cruciate Ligament of Rabbit Knee Joint: A Histological and Biomechanical Study. BMC Musculoskeletal Disorders 2023, 24, doi:10.118...

    2023 doi

  38. [46]

    The Degradation Regulation of 3D Printed Scaffolds for Promotion of Osteogenesis and in Vivo Tracking

    Li, X.; Zou, Q.; Wei, J.; Li, W. The Degradation Regulation of 3D Printed Scaffolds for Promotion of Osteogenesis and in Vivo Tracking. Composites Part B: Engineering 2021, 222, doi:10.1016/j.compositesb.2021.109084

    2021

  39. [47]

    Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Silk -Collagen Scaffold Modified by Hydroxya patite at Both Ends: A Histological and Biomechanical Study

    Bi, F.; Chen, Y .; Liu, J.; Wang, Y .; Xu, D.; Tian, K. Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Silk -Collagen Scaffold Modified by Hydroxya patite at Both Ends: A Histological and Biomechanical Study. Journal of Orthopaedic Surgery and Research 202...

    2021 doi

  40. [48]

    Strong and Tough β -TCP/PCL Composite Scaffolds with Gradient Structure for Bone Tissue Engineering: Development and Evaluation

    Shao, X.; Wu, Y .; Ding, M.; Chen, X.; Zhou, T.; Huang, C.; Wang, X.; Zong, C.; Liu, Y .; Tian, L.; et al. Strong and Tough β -TCP/PCL Composite Scaffolds with Gradient Structure for Bone Tissue Engineering: Development and Evaluation. Ceramics International 2024, 50, 31905–31...

    2024 doi

  41. [49]

    T GF–Β3 Loaded Electrospun Polycaprolacton Fibre Scaffolds for Rotator Cuff Tear Repair: An in Vivo Study in Rats

    Reifenrath, J.; Wellmann, M.; Kempfert, M.; Angrisani, N.; Welke, B.; Gniesmer, S.; Kampmann, A.; Menzel, H.; Willbold, E. T GF–Β3 Loaded Electrospun Polycaprolacton Fibre Scaffolds for Rotator Cuff Tear Repair: An in Vivo Study in Rats. International Journal of Molecular Scie...

    2020 doi

  42. [50]

    Application of Biomimetic Double-Layer Biofilm Stent in Arthroscopic Rotator Cuff Repair: A Protocol of Randomized Controlled Trial

    Ma, L.; Xu, Y .; Xu, X.; Pan, Q.; Xu, Y . Application of Biomimetic Double-Layer Biofilm Stent in Arthroscopic Rotator Cuff Repair: A Protocol of Randomized Controlled Trial. Medicine 2021, 100, e23960, doi:10.1097/MD.0000000000023960

    2021 doi

  43. [51]

    Topographical and Compositional Gradient Tubular Scaffold for Bone to Tendon Interface Regeneration

    Bianchi, E.; Faccendini, A.; Del Favero, E.; Ricci, C.; Caliogna, L.; Vigan i, B.; Pavesi, F.C.; 11 Perotti, C.; Domingues, R.M.A.; Gomes, M.E.; et al. Topographical and Compositional Gradient Tubular Scaffold for Bone to Tendon Interface Regeneration. Pharmaceutics 2022, 14, ...

    2022 doi

  44. [52]

    -W.; Min, K

    Jang, J. -W.; Min, K. -E.; Kim, C.; Shin, J.; Lee, J.; Yi, S. Review: Scaffold Characteristics, Fabrication Methods, and Biomaterials for the Bone Tissue Engineering. International Journal of Precision Engineering and Manufacturing 2023, 24, 511 –529, doi:10.1007/s12541-022-00755-7

    2023 doi

  45. [53]

    Electrospinning Technology: A Promising Approach for Tendon –Bone Interface Tissue Engineering

    Liang, C.; Fan, Z.; Zhang, Z.; Wang, P .; Deng, H.; Tao, J. Electrospinning Technology: A Promising Approach for Tendon –Bone Interface Tissue Engineering. RSC Adv. 2024, 14, 26077–26090, doi:10.1039/D4RA04043K

    2024 doi

  46. [54]

    Photothermal-Triggered Structural Change of Nanofiber Scaffold Integrating with Graded Mineralization to Promote Tendon –Bone Healing

    Yu, C.; Wang, T.; Diao, H.; Liu, N.; Zhang, Y .; Jiang, H.; Zhao, P .; Shan, Z.; Sun, Z.; Wu, T.; et al. Photothermal-Triggered Structural Change of Nanofiber Scaffold Integrating with Graded Mineralization to Promote Tendon –Bone Healing. Adv. Fiber Mater. 2022, 4, 908 –922, ...

    2022 doi

  47. [55]

    Bipolar Metal Flexible Electrospun Fi brous Membrane Based on Metal -Organic Framework for Gradient Healing of Tendon -to-Bone Interface Regeneration

    Yang, R.; Zheng, Y .; Zhang, Y .; Li, G.; Xu, Y .; Zhang, Y .; Xu, Y .; Zhuang, C.; Yu, P .; Deng, L.; et al. Bipolar Metal Flexible Electrospun Fi brous Membrane Based on Metal -Organic Framework for Gradient Healing of Tendon -to-Bone Interface Regeneration. Adv Healthc Mate...

    2022 doi

  48. [56]

    Bi -Lineage Inducible and Immunoregulatory Electrospun Fibers Scaffolds for Synchronous Regeneration of Tendon -to-Bone Interface

    Gao, H.; Wang, L.; Lin, Z.; Jin, H.; Lyu, Y .; Kang, Y .; Zhu, T.; Zhao, J.; Jiang, J. Bi -Lineage Inducible and Immunoregulatory Electrospun Fibers Scaffolds for Synchronous Regeneration of Tendon -to-Bone Interface. Mater Today Bio 2023, 22, 100749, doi:10.1016/j.mtbio.2023.100749

    2023

  49. [57]

    3D Bioprinted Multi-Layered Cell Constructs with Gradient Core-Shell Interface for Tendon-to-Bone Tissue Regeneration

    Kim, W.; Kwon, D.R.; Lee, H.; Lee, J.; Moon, Y .S.; Lee, S.C.; Kim, G.H. 3D Bioprinted Multi-Layered Cell Constructs with Gradient Core-Shell Interface for Tendon-to-Bone Tissue Regeneration. Bioactive Materials 2025, 43, 471 –490, doi:10.1016/j.bioactmat.2024.10.002

    2025 doi

  50. [58]

    -H.; Shalumon, K.T.; Kao, H

    Govindaraju, D.T.; Chen, C. -H.; Shalumon, K.T.; Kao, H. -H.; Chen, J. -P . Bioactive Nanostructured Scaffold -Based Approach for Tendon and Ligament Tissue Engineering. Nanomaterials 2023, 13, 1847, doi:10.3390/nano13121847

    2023 doi

  51. [59]

    Biomimetic Scaffolds for Tendon Tissue Regeneration

    Huang, L.; Chen, L.; Chen, H.; Wang, M.; Jin, L.; Zhou, S.; Gao, L.; Li, R.; Li, Q.; Wang, H.; et al. Biomimetic Scaffolds for Tendon Tissue Regeneration. Biomimetics 2023, 8, 246, doi:10.3390/biomimetics8020246

    2023 doi

Pith tools

Reviewed August 7, 2026 · model on record in the stance chip above.