Isoform reconstruction using short RNA-Seq reads by maximum likelihood is NP-hard

Rui Jiang; Tianyang Li; Xuegong Zhang

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Isoform reconstruction using short RNA-Seq reads by maximum likelihood is NP-hard

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arxiv 1305.0916 v1 pith:5AB5ZH4Q submitted 2013-05-04 q-bio.QM q-bio.GN

Tianyang Li , Rui Jiang , Xuegong Zhang This is my paper

classification q-bio.QMq-bio.GN

keywords isoformlikelihoodmaximumreconstructionnp-hardreadsrna-seqshort

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Maximum likelihood is a popular technique for isoform reconstruction. Here, we show that isoform reconstruction using short RNA-Seq reads by maximum likelihood is NP-hard.

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