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Where Bayes tweaks Gauss: Conditionally Gaussian priors for stable multi-dipole estimation

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arxiv 2006.04141 v1 pith:7XUFDPWY submitted 2020-06-07 stat.AP q-bio.QMstat.ME

classification stat.APq-bio.QMstat.ME
keywords conditionallyestimationgaussiangeneralizationhyperparameterstablealgorithmapproximation
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We present a very simple yet powerful generalization of a previously described model and algorithm for estimation of multiple dipoles from magneto/electro-encephalographic data. Specifically, the generalization consists in the introduction of a log-uniform hyperprior on the standard deviation of a set of conditionally linear/Gaussian variables. We use numerical simulations and an experimental dataset to show that the approximation to the posterior distribution remains extremely stable under a wide range of values of the hyperparameter, virtually removing the dependence on the hyperparameter.

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    DP-MoSt fits continuous sigmoidal disease trajectories and uses a two-level mixture to identify which biomarkers split into sub-trajectories and which patients belong to each subgroup.

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