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arxiv: 2108.09499 · v2 · pith:FJULQG6Z · submitted 2021-08-21 · q-bio.OT · eess.IV

MITI Minimum Information guidelines for highly multiplexed tissue images

Denis Schapiro , Clarence Yapp , Artem Sokolov , Sheila M. Reynolds , Yu-An Chen , Damir Sudar , Yubin Xie , Jeremy L. Muhlich
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Raquel Arias-Camison Sarah Arena Adam J. Taylor Milen Nikolov Madison Tyler Jia-Ren Lin Erik A. Burlingame Human Tumor Atlas Network Young H. Chang Samouil L Farhi V\'esteinn Thorsson Nithya Venkatamohan Julia L. Drewes Dana Pe'er David A. Gutman Markus D. Herrmann Nils Gehlenborg Peter Bankhead Joseph T. Roland John M. Herndon Michael P. Snyder Michael Angelo Garry Nolan Jason R. Swedlow Nikolaus Schultz Daniel T. Merrick Sarah A. Mazzilli Ethan Cerami Scott J. Rodig Sandro Santagata Peter K. Sorger
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classification q-bio.OT eess.IV
keywords datatissuehighlymultiplexedimagesinformationmicroscopyminimum
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The imminent release of tissue atlases combining multi-channel microscopy with single cell sequencing and other omics data from normal and diseased specimens creates an urgent need for data and metadata standards that guide data deposition, curation and release. We describe a Minimum Information about highly multiplexed Tissue Imaging (MITI) standard that applies best practices developed for genomics and other microscopy data to highly multiplexed tissue images and traditional histology.

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