Mean curvature flow with generic initial data

We show that the mean curvature flow of generic closed surfaces in $\mathbb{R}^{3}$ avoids asymptotically conical and non-spherical compact singularities. We also show that the mean curvature flow of generic closed low-entropy hypersurfaces in $\mathbb{R}^{4}$ is smooth until it disappears in a round point. The main technical ingredient is a long-time existence and uniqueness result for ancient mean curvature flows that lie on one side of asymptotically conical or compact shrinking solitons.