The observed spatial distribution of matter on scales ranging from 100kpc to 1Gpc is inconsistent with the standard dark-matter-based cosmological models

The spatial arrangement of galaxies (of satellites on a scale of 100kpc) as well as their three-dimensional distribution in galaxy groups such as the Local Group (on a scale of 1Mpc), the distribution of galaxies in the nearby volume of galaxies (on a scale of 8Mpc) and in the nearby Universe (on a scale of 1Gpc) is considered. There is further evidence that the CMB shows irregularities and for anisotropic cosmic expansion. The overall impression one obtains, given the best data we have, is matter to be arranged as not expected in the dark-matter based standard model of cosmology (SMoC). There appears to be too much structure, regularity and organisation. Dynamical friction on the dark matter halos is a strong direct test for the presence of dark matter particles, but this process does not appear to be operative in the real Universe. This evidence suggests strongly that dynamically relevant dark matter does not exist and therefore cosmology remains largely not understood theoretically. More-accepted awareness of this case would by itself constitute a major advance in research providing fabulous opportunities for bright minds, and the observational data strongly suggest that gravitation must be effectively Milgromian, corresponding to a generalized Poisson equation in the classical limit. Thus, physical cosmology offers a significant historically relevant opportunity for ground-breaking work, at least for those daring to do so.