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arxiv: q-bio/0511051 · v1 · submitted 2005-11-30 · 🧬 q-bio.PE · q-bio.GN

Quasispecies and recombination

classification 🧬 q-bio.PE q-bio.GN
keywords recombinationerrorfitnessfixedmutationquasispeciesratesstable
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Recombination is introduced into Eigen's theory of quasispecies evolution. Comparing numerical simulations of the rate equations in the non-recombining and recombining cases show that recombination has a strong effect on the error threshold and, for a wide range of mutation rates, gives rise to two stable fixed points in the dynamics. This bi-stability results in the existence of two error thresholds. We prove that, under some assumptions on the fitness landscape but for general crossover probability, a fixed point localized about the sequence with superior fitness is globally stable for low mutation rates.

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