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pith:2GWQAXOI

pith:2026:2GWQAXOIJPRNPM33SVM73IW5LZ
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Attention-Based Multimodal Survival Prediction with Cross-Modal Bilinear Fusion

Hassan Keshvarikhojasteh, Josien P.W. Pluim, Mitko Veta

A multimodal model fuses histology, RNA-seq, and clinical data with low-rank bilinear pooling to predict survival more accurately than concatenation baselines.

arxiv:2605.13897 v1 · 2026-05-12 · q-bio.QM · cs.LG

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\pithnumber{2GWQAXOIJPRNPM33SVM73IW5LZ}

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3 Author claim open · sign in to claim
4 Citations open
5 Replications open
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Claims

C1strongest claim

Experiments on the CHIMERA challenge dataset demonstrate improved predictive performance over concatenation-based baselines and competitive generalization on hidden evaluation cohorts.

C2weakest assumption

That the low-rank bilinear fusion captures the clinically relevant conditional interactions across histology, RNA-seq, and clinical modalities without discarding important information, and that the Kaplan-Meier calibration step produces well-calibrated survival estimates on the target population.

C3one line summary

A multimodal survival model using attention-based histology features, RNA-seq encoders, and low-rank bilinear fusion shows improved performance over concatenation baselines on the CHIMERA dataset for HR-NMIBC.

References

14 extracted · 14 resolved · 2 Pith anchors

[1] Chimera challenge – combining histology, medical imaging and molecular data for medical prognosis and diagnosis.https://chimera.grand-challenge.org(2025), accessed: 2026-02-04 2025
[2] IEEE Transactions on Pattern Analysis and Machine Intelligence 41(2), 423–443 (2019) 2019
[3] Cheerla, A., Gevaert, O.: Deep learning with multimodal representation for pan- cancer prognosis prediction. Bioinformatics35(14), i446–i454 (2019) 2019
[4] Nature medicine30(3), 850–862 (2024) 2024
[5] IEEE Transactions on Medical Imaging41(4), 757–770 (2020) 2020

Formal links

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Receipt and verification
First computed 2026-05-17T23:39:18.985332Z
Builder pith-number-builder-2026-05-17-v1
Signature Pith Ed25519 (pith-v1-2026-05) · public key
Schema pith-number/v1.0

Canonical hash

d1ad005dc84be2d7b37b9559fda2dd5e55e42c537ed7d291907ce93dfa916a8d

Aliases

arxiv: 2605.13897 · arxiv_version: 2605.13897v1 · doi: 10.48550/arxiv.2605.13897 · pith_short_12: 2GWQAXOIJPRN · pith_short_16: 2GWQAXOIJPRNPM33 · pith_short_8: 2GWQAXOI
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Verify this Pith Number yourself
curl -sH 'Accept: application/ld+json' https://pith.science/pith/2GWQAXOIJPRNPM33SVM73IW5LZ \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: d1ad005dc84be2d7b37b9559fda2dd5e55e42c537ed7d291907ce93dfa916a8d
Canonical record JSON
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    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "q-bio.QM",
    "submitted_at": "2026-05-12T13:09:25Z",
    "title_canon_sha256": "168bd8626c685ea98bd3dd50b799d539af73de41837a212d8c22a5912370d276"
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    "kind": "arxiv",
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