Pith Number

pith:3V7XC23T

pith:2026:3V7XC23TUPJJ5J7JTH33Q4ZOB3

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A Brownian dynamics study of liquid-liquid phase separation in multi-scale chromatin networks

Judith Min\'e-Hattab, L\'ea Beaul\`es, Pierre Illien, Vincent Dahirel

Chromatin fiber networks control the positioning and morphology of phase-separated protein droplets through interactions analogous to wetting transitions.

arxiv:2605.14516 v1 · 2026-05-14 · cond-mat.soft · physics.bio-ph

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Claims

C1strongest claim

We show that protein-fiber interactions strongly influence droplet positioning relative to the substrate, in a manner analogous to wetting transitions in soft condensed matter systems. Both local geometric constraints and global network organization markedly affect droplet size, morphology, and multiplicity. In addition, large-scale asymmetries in fiber organization can induce robust spatial localization of the dense phase.

C2weakest assumption

The minimal model of Lennard-Jones particles interacting with fixed fibrous substrates sufficiently captures the dominant physical effects of real chromatin on phase-separating proteins, without needing explicit dynamics of the fibers themselves or additional molecular details.

C3one line summary

Brownian dynamics simulations demonstrate that multi-scale chromatin fiber geometry and network organization control the positioning, size, morphology, and multiplicity of liquid-liquid phase separated condensates via protein-fiber interactions.

References

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[1] Linear fiber There is a large variety of chromatin geometries within the length scales under study here (nucleosomes to con- densates, 10 nm to 1µm). In order to understand the possible interactions o

[2] There can be intersections within the same fiber if there is a loop [59, 60], or between dif- ferent fibers

[3] Droplet identification Two proteins are considered as part of the same droplet if they are closer than a threshold distancer cut of each other. The value ofr cut is chosen as the distance at 12 the fi

[4] It is estimated from the positionsr i = (rix, riy, riz) of the nparti proteins in each droplet

[5] Droplet localization To quantify the localization of the droplets with re- spect to the fibers, we calculate the pair correlation func- tiong DN (r) between the center of mass of a droplet and the pos

Receipt and verification

First computed	2026-05-17T23:39:06.125385Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

dd7f716b73a3d29ea7e999f7b8732e0ee3137d22fc44b141c7658c39b067556a

Aliases

arxiv: 2605.14516 · arxiv_version: 2605.14516v1 · doi: 10.48550/arxiv.2605.14516 · pith_short_12: 3V7XC23TUPJJ · pith_short_16: 3V7XC23TUPJJ5J7J · pith_short_8: 3V7XC23T

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Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/3V7XC23TUPJJ5J7JTH33Q4ZOB3 \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: dd7f716b73a3d29ea7e999f7b8732e0ee3137d22fc44b141c7658c39b067556a

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "003f93549af2a40f5fbbfb3af18a97420904b5658b671f4d0a45230e9f90ed97",
    "cross_cats_sorted": [
      "physics.bio-ph"
    ],
    "license": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
    "primary_cat": "cond-mat.soft",
    "submitted_at": "2026-05-14T07:59:51Z",
    "title_canon_sha256": "ffc97b8860bed82d7f56c69aaa62d877947cd8565138bce3530861a61f9258c2"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.14516",
    "kind": "arxiv",
    "version": 1
  }
}