Pith Number

pith:6OS4MLXN

pith:2026:6OS4MLXNJIPKH5JQSNT74LAESF

not attested not anchored not stored refs resolved

Ultra-high frequency ultrasound imaging and quantification of microvascular flow in xenograft renal cell carcinoma in an avian chorioallantoic membrane model

Christine E.M. Demore, David E. Goertz Hon S. Leong, Emmanuel Cherin, Justin Xu, Sara Mar

Motion-compensated interframe subtraction enables ultra-high frequency ultrasound to quantify microvascular flow changes in CAM tumor models.

arxiv:2603.05658 v2 · 2026-03-05 · physics.med-ph

Open paper page JSON Open Graph Bundle Merged state Verified badge What is a Pith Number?

Add to your LaTeX paper

\usepackage{pith}
\pithnumber{6OS4MLXNJIPKH5JQSNT74LAESF}

Prints a linked badge after your title and injects PDF metadata. Compiles on arXiv. Learn more · Embed verified badge

Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

The UHFUS imaging methods detected a significant decrease in blood flow metrics in treated versus control tumors. An effective imaging pipeline was developed for the assessment of the treatment response of CAM PDX models in a clinically relevant timeframe.

C2weakest assumption

That interframe subtraction after motion compensation isolates true microvascular flow signals rather than residual motion artifacts or noise in the CAM model, and that the chosen implementation details (thresholds, filter order) generalize beyond the specific phantom and in-vivo datasets shown.

C3one line summary

An interframe subtraction pipeline with motion compensation on ultra-high frequency ultrasound detects reduced microvascular flow in Sunitinib-treated renal cell carcinoma xenografts in the CAM model.

References

65 extracted · 65 resolved · 0 Pith anchors

[1] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

[2] embryonic lung 2075

[3] Non rigid frame registration was used to compensate in-plane motion

[4] In the case of stationary tissue, this operation removes tissue signals, and the remaining signals are associated solely with moving blood (Eq

[5] 4 with 𝑦̅ the average over N clutter filtered frames 𝑦, where N= 630 − 𝑚 maximum

Receipt and verification

First computed	2026-05-18T02:45:04.992423Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

f3a5c62eed4a1ea3f5309367fe2c049174ea349b7714b9a6c38748acb4be3ad7

Aliases

arxiv: 2603.05658 · arxiv_version: 2603.05658v2 · doi: 10.48550/arxiv.2603.05658 · pith_short_12: 6OS4MLXNJIPK · pith_short_16: 6OS4MLXNJIPKH5JQ · pith_short_8: 6OS4MLXN

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/6OS4MLXNJIPKH5JQSNT74LAESF \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: f3a5c62eed4a1ea3f5309367fe2c049174ea349b7714b9a6c38748acb4be3ad7

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "c372cbb4d76803aea4dfde5109bcca9b026c680244bd4e46dd8e6a266fb9f149",
    "cross_cats_sorted": [],
    "license": "http://creativecommons.org/licenses/by-nc-nd/4.0/",
    "primary_cat": "physics.med-ph",
    "submitted_at": "2026-03-05T20:19:50Z",
    "title_canon_sha256": "33dbabbfa39698cff77d9223ea34d94614ee8035e94e8a4ce580d9a99a787143"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2603.05658",
    "kind": "arxiv",
    "version": 2
  }
}