Pith Number

pith:76THIISJ

pith:2025:76THIISJ4KEGUC2GOBHHEXS6YD

not attested not anchored not stored refs pending

Improving sampling of binding free energy differences between covalently bound ligands in alternate binding pockets using MT-REXEE

Anika J. Friedman, Jerome M. Fox, Michael R. Shirts

arxiv:2508.06720 v3 · 2025-08-08 · physics.bio-ph

Open paper page JSON Open Graph Bundle Merged state Verified badge What is a Pith Number?

Add to your LaTeX paper

\usepackage{pith}
\pithnumber{76THIISJ4KEGUC2GOBHHEXS6YD}

Prints a linked badge after your title and injects PDF metadata. Compiles on arXiv. Learn more · Embed verified badge

Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Receipt and verification

First computed	2026-06-30T01:17:25.254718Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

ffa6742249e2886a0b46704e725e5ec0fa1ef2fc8f25092775fd2c125f1d9bc5

Aliases

arxiv: 2508.06720 · arxiv_version: 2508.06720v3 · doi: 10.48550/arxiv.2508.06720 · pith_short_12: 76THIISJ4KEG · pith_short_16: 76THIISJ4KEGUC2G · pith_short_8: 76THIISJ

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/76THIISJ4KEGUC2GOBHHEXS6YD \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: ffa6742249e2886a0b46704e725e5ec0fa1ef2fc8f25092775fd2c125f1d9bc5

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "f30b6e1b36347adc9b06d27c8d671b694a39fe3c8d1933919812ac11a8db70f5",
    "cross_cats_sorted": [],
    "license": "http://creativecommons.org/licenses/by-sa/4.0/",
    "primary_cat": "physics.bio-ph",
    "submitted_at": "2025-08-08T21:38:46Z",
    "title_canon_sha256": "33f52951a558eae51c595a8d9ba0fec44c8ee4191845ddc9dfa7ecb2d35de1b6"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2508.06720",
    "kind": "arxiv",
    "version": 3
  }
}