Pith Number

pith:BF7337SO

pith:2026:BF7337SORMCIUKJ4FODD6V7SH7

not attested not anchored not stored refs pending

Towards A Generative Protein Evolution Machine with DPLM-Evo

Jiasheng Ye, Liang Hong, Quanquan Gu, Shujian Huang, Xinyou Wang, Yu Li, Zaixiang Zheng

DPLM-Evo models protein evolution by predicting explicit substitutions, insertions, and deletions in a discrete diffusion process.

arxiv:2605.00182 v3 · 2026-04-30 · cs.LG

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\usepackage{pith}
\pithnumber{BF7337SORMCIUKJ4FODD6V7SH7}

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Record completeness

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2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

DPLM-Evo achieves state-of-the-art mutation effect prediction performance on ProteinGym in the single-sequence setting and enables variable-length simulated evolution and post-editing of existing proteins via explicit edit trajectories.

C2weakest assumption

That the contextualized evolutionary noising kernel produces biologically realistic, context-dependent mutation patterns and that decoupling the upsampled latent alignment space from the observed sequence space introduces no artifacts in indel generation.

C3one line summary

DPLM-Evo adds explicit edit operations and a latent alignment space to discrete diffusion protein models, achieving SOTA single-sequence mutation effect prediction on ProteinGym while supporting variable-length generation.

Receipt and verification

First computed	2026-06-04T01:09:50.238353Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

097fbdfe4e8b048a293c2b863f57f23ffb15e4ca37f40b4192524ae8e5080fe8

Aliases

arxiv: 2605.00182 · arxiv_version: 2605.00182v3 · doi: 10.48550/arxiv.2605.00182 · pith_short_12: BF7337SORMCI · pith_short_16: BF7337SORMCIUKJ4 · pith_short_8: BF7337SO

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/BF7337SORMCIUKJ4FODD6V7SH7 \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 097fbdfe4e8b048a293c2b863f57f23ffb15e4ca37f40b4192524ae8e5080fe8

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "a5ab936f8420e1943d47272159b2508daa8836b3c6f7121ee2aa39f3bd0f9318",
    "cross_cats_sorted": [],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "cs.LG",
    "submitted_at": "2026-04-30T19:59:07Z",
    "title_canon_sha256": "2f63891bfb3832560a14e24df0b5a7857660e4d952db7b0c56c45294bc9f8660"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.00182",
    "kind": "arxiv",
    "version": 3
  }
}