Pith Number

pith:HC2TV4HW

pith:2026:HC2TV4HW3DUT6LZORNBXSHBO5K

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A geometry-dependent, force balance-driven model of Staphylococcus epidermidis biofilm cell cluster detachment

Elizabeth J. Stewart, Jasmine A.F. Kreig, Rayanne A. Luke, Sarah D. Olson, Yuehui Xu, Zhuoran Wang

A force-balance model shows that cluster geometry and local EPS adhesion control which bacterial groups detach from S. epidermidis biofilms.

arxiv:2605.15364 v1 · 2026-05-14 · q-bio.QM · math.GM

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\usepackage{pith}
\pithnumber{HC2TV4HW3DUT6LZORNBXSHBO5K}

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Record completeness

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Claims

C1strongest claim

Our detachment model accounts for drag and adhesion in tagged sections of the biofilm determined by the cluster geometry and local arrangement of bacteria and EPS. A stickiness parameter controls local EPS adhesion strength, which is modulated to disrupt EPS biomass.

C2weakest assumption

That experimental microstructural features from 24-hour S. epidermidis biofilms can accurately benchmark the simulated biofilm structure so that varying the stickiness parameter produces reliable predictions of detached cluster properties under EPS disruption.

C3one line summary

A geometry-dependent force balance model simulates detachment of cell clusters from S. epidermidis biofilms using a stickiness parameter for EPS adhesion and experimental benchmarking to examine effects of matrix disruption.

References

59 extracted · 59 resolved · 0 Pith anchors

[1] S. Jonblat, F. As-Sadi, K. Zibara, M. Sabban, V . Dermesrobian, A. Khoury, M. Kallassy, A. Chokr, Int Microbiol 27(3), 831 (2024). DOI 10.1007/s10123-023-00433-2. Epub 2023 Oct 12 2024 · doi:10.1007/s10123-023-00433-2

[2] M. Assefa, A. Amare, Infect Drug Resis 15, 5061 (2020) 2020

[3] Otto, Nat Rev Microbiol 7, 555 (2009) 2009

[4] M. Alhede, M. Lorenz, B. Fritz, P . Jensen, H. Ring, L. Bay, T. Bjarnsholt, Med Microbiol Immunol 209, 669 (2020) 2020

[5] H. Flemming, J. Wingender, Water Sci Technol 43(6), 1 (2001) 2001

Formal links

2 machine-checked theorem links

Receipt and verification

First computed	2026-05-20T00:00:54.593118Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

38b53af0f6d8e93f2f2e8b43791c2eeaa8a0b8f5d6b6e371e7255976fb19aa44

Aliases

arxiv: 2605.15364 · arxiv_version: 2605.15364v1 · doi: 10.48550/arxiv.2605.15364 · pith_short_12: HC2TV4HW3DUT · pith_short_16: HC2TV4HW3DUT6LZO · pith_short_8: HC2TV4HW

Agent API

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Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/HC2TV4HW3DUT6LZORNBXSHBO5K \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 38b53af0f6d8e93f2f2e8b43791c2eeaa8a0b8f5d6b6e371e7255976fb19aa44

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "2f74699856505699e587dc3f90d532f5eff7f4bb4b490245069bf4488b878403",
    "cross_cats_sorted": [
      "math.GM"
    ],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "q-bio.QM",
    "submitted_at": "2026-05-14T19:43:38Z",
    "title_canon_sha256": "55ad120194113a226d29b983de6f0a658c67b88e8c7a1cc8fc6915ee5764c538"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.15364",
    "kind": "arxiv",
    "version": 1
  }
}