Pith Number

pith:HOPF4JOM

pith:2026:HOPF4JOMOZL5OYZAJJIYTNHWDZ

not attested not anchored not stored refs pending

Probe Before You Edit: Probing-Guided Molecular Optimization for LLM Agents in Structure-Based Drug Design

James Kwok, Weiyu Chen, Yaqing Wang, Zaifei Yang

arxiv:2606.00555 v1 · 2026-05-30 · cs.AI · q-bio.BM

Open paper page JSON Open Graph Bundle Merged state Verified badge What is a Pith Number?

Add to your LaTeX paper

\usepackage{pith}
\pithnumber{HOPF4JOMOZL5OYZAJJIYTNHWDZ}

Prints a linked badge after your title and injects PDF metadata. Compiles on arXiv. Learn more · Embed verified badge

Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Receipt and verification

First computed	2026-06-02T01:03:58.091775Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

3b9e5e25cc7657d763204a5189b4f61e4ce3517741bcd0ac53e9893b34b9db58

Aliases

arxiv: 2606.00555 · arxiv_version: 2606.00555v1 · doi: 10.48550/arxiv.2606.00555 · pith_short_12: HOPF4JOMOZL5 · pith_short_16: HOPF4JOMOZL5OYZA · pith_short_8: HOPF4JOM

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/HOPF4JOMOZL5OYZAJJIYTNHWDZ \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 3b9e5e25cc7657d763204a5189b4f61e4ce3517741bcd0ac53e9893b34b9db58

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "fb1506b21f6e1b84b97b2b06da25aac735fb5c521c26476f5e738f71168126a5",
    "cross_cats_sorted": [
      "q-bio.BM"
    ],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "cs.AI",
    "submitted_at": "2026-05-30T06:06:51Z",
    "title_canon_sha256": "1fe312b4bf5bc0ba17e416c8ef430f7331e095f75f6f6555ed0d0078acd61e5f"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2606.00555",
    "kind": "arxiv",
    "version": 1
  }
}