Pith Number

pith:HSLQ6M3W

pith:2026:HSLQ6M3WOJJS3IP7CXGSHU4HIG

not attested not anchored not stored refs pending

Contextual Invertible World Models: A Neuro-Symbolic Agentic Framework for Colorectal Cancer Drug Response

Christopher Baker, Hui Wang, Karen Rafferty, Tianyu Ren

A neuro-symbolic framework integrates machine learning emulation with LLM reasoning to predict colorectal cancer drug responses and identify APC/Wnt pathway dominance.

arxiv:2603.02274 v3 · 2026-03-01 · q-bio.QM · cs.AI

Open paper page JSON Open Graph Bundle Merged state Verified badge What is a Pith Number?

Add to your LaTeX paper

\usepackage{pith}
\pithnumber{HSLQ6M3WOJJS3IP7CXGSHU4HIG}

Prints a linked badge after your title and injects PDF metadata. Compiles on arXiv. Learn more · Embed verified badge

Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

Utilising a zero-leakage forensic pipeline on the Sanger GDSC dataset (N = 83), we achieve a robust predictive correlation (r = 0.447, p = 2.30e-05). ... identifying a hierarchical dominance of the APC/Wnt-axis over the p53 apoptotic pathway. Validated against human clinical profiles (TCGA-COAD proxy, p = 0.0357)

C2weakest assumption

The assumption that the LLM-based reasoning layer delivers genuine mechanistic insight rather than plausible post-hoc explanations, and that the small N=83 zero-leakage pipeline plus TCGA proxy validation generalizes beyond the specific dataset and model choices.

C3one line summary

CIWM neuro-symbolic framework reports r=0.447 correlation on GDSC N=83 data for colorectal cancer drug response and finds APC/Wnt pathway dominance over p53 via in silico perturbations validated on TCGA.

Formal links

2 machine-checked theorem links

Receipt and verification

First computed	2026-06-12T01:08:23.433652Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

3c970f337672532da1ff15cd23d38741a1389f16442f24947859456646621381

Aliases

arxiv: 2603.02274 · arxiv_version: 2603.02274v3 · doi: 10.48550/arxiv.2603.02274 · pith_short_12: HSLQ6M3WOJJS · pith_short_16: HSLQ6M3WOJJS3IP7 · pith_short_8: HSLQ6M3W

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/HSLQ6M3WOJJS3IP7CXGSHU4HIG \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 3c970f337672532da1ff15cd23d38741a1389f16442f24947859456646621381

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "0fd243c45d56fba52bc18dcd455d85c303b5a40c21fb6e11b839ee27ccfbf2c0",
    "cross_cats_sorted": [
      "cs.AI"
    ],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "q-bio.QM",
    "submitted_at": "2026-03-01T16:15:58Z",
    "title_canon_sha256": "870b59b325aeec8ea29f3119e6ab80804328e73a63c16feb1d301954a9580cf1"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2603.02274",
    "kind": "arxiv",
    "version": 3
  }
}