Pith Number

pith:J2IKCVXE

pith:2026:J2IKCVXEVOUQ2DG2MNWYT6SEEV

not attested not anchored not stored refs pending

When Brains Disagree: Biological Ambiguity Underlies the Challenge of Amyloid PET Synthesis from Structural MRI

David M. Cash, Hojjat Azadbakht, Hui Zhang, Louise E. G. Baron, Philip S. J. Weston, Ross Callaghan

Biological ambiguity from decoupled brain processes makes MRI-to-amyloid PET synthesis inherently inconsistent.

arxiv:2605.11867 v2 · 2026-05-12 · cs.CV

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\usepackage{pith}
\pithnumber{J2IKCVXEVOUQ2DG2MNWYT6SEEV}

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Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

limited and inconsistent performance in MRI-to-amyloid PET synthesis is explained by intrinsic biological ambiguity, and that stable, meaningful progress requires multimodal integration rather than architectural complexity.

C2weakest assumption

That stratifying paired MRI-PET data by amyloid and neurodegeneration status cleanly isolates unambiguous mappings without introducing selection bias or unmeasured confounders that could explain the performance collapse.

C3one line summary

Biological ambiguity between neurodegeneration on MRI and amyloid on PET makes one-to-one synthesis ill-posed, but stratifying data or adding plasma biomarkers restores performance.

Formal links

2 machine-checked theorem links

Receipt and verification

First computed	2026-05-27T01:05:56.985270Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

4e90a156e4aba90d0cda636d89fa442569e9dff627e77fb9acc6d56cc019ecb8

Aliases

arxiv: 2605.11867 · arxiv_version: 2605.11867v2 · doi: 10.48550/arxiv.2605.11867 · pith_short_12: J2IKCVXEVOUQ · pith_short_16: J2IKCVXEVOUQ2DG2 · pith_short_8: J2IKCVXE

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/J2IKCVXEVOUQ2DG2MNWYT6SEEV \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 4e90a156e4aba90d0cda636d89fa442569e9dff627e77fb9acc6d56cc019ecb8

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "dbe6adf0ddba4a3fc8a2a190972ab215d0849e5c5044339e78955cc460c790a6",
    "cross_cats_sorted": [],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "cs.CV",
    "submitted_at": "2026-05-12T09:47:44Z",
    "title_canon_sha256": "870c6015bb3cc65b5bb135f308375c449e999fea6b3846009142358542820084"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2605.11867",
    "kind": "arxiv",
    "version": 2
  }
}